ID   28SC-ES
AC   CVCL_EP74
SY   28SC-Endotoxin Sensitive
DR   cancercelllines; CVCL_EP74
DR   JCRB; JCRB1647
DR   Wikidata; Q54583799
RX   PubMed=12944673;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. On the basis of the STR profile the parent cell line (SC) seems to be a U-937 derivative.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00526.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): JCRB=JCRB1647
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 10,12
ST   D16S539: 12
ST   D5S818: 10,12
ST   D7S820: 9,11
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 15
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6444 ! SC [Human contaminated U-937]
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 26-09-16; Last updated: 10-04-25; Version: 19
//
RX   PubMed=12944673;
RA   Yamamoto, Akihiko
RA   Sakai, Takeo
RA   Ochiai, Masaki
RA   Kamachi, Kazunari
RA   Kataoka, Michiyo
RA   Toyoizumi, Hiromi
RA   Horiuchi, Yoshinobu
RT   "A cell line assay system for predicting the response of human blood
RT   to endotoxin.";
RL   Jpn. J. Infect. Dis. 56:93-100(2003).
//