ID   K-562 VPS13A/VPS13C DKO clone 2
AC   CVCL_E9XW
SY   K562 VPS13A/VPS13C DKO clone#2
RX   PubMed=40463036;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas12a; HGNC; HGNC:1908; VPS13A.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:23594; VPS13C.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 14-08-25; Last updated: 14-08-25; Version: 1
//
RX   PubMed=40463036; DOI=10.1101/2025.05.09.653147; PMCID=PMC12132566;
RA   Xu, Peng
RA   Mancuso, Rubia Isler
RA   Leonzino, Marianna
RA   Zeiss, Caroline J.
RA   Krause, Diane S.
RA   De Camilli, Pietro
RT   "Defect in hematopoiesis and embryonic lethality at midgestation of
RT   Vps13a/Vps13c double knockout mice.";
RL   bioRxiv 2025:05.09.653147-05.09.653147(2025).
//