ID   MT1
AC   CVCL_E8BN
DR   GEO; GSM260649
DR   GEO; GSM260650
DR   GEO; GSM260651
DR   GEO; GSM260652
RX   PubMed=3745200;
RX   PubMed=8341649;
RX   PubMed=18805990;
CC   Population: Caucasian.
CC   Characteristics: Able to survive the cytotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Sensitive to mutagenesis by MNNG and display a mutator phenotype (PubMed=3745200).
CC   Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
CC   Sequence variation: Mutation; HGNC; HGNC:11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (PubMed=33198927).
CC   Sequence variation: Mutation; HGNC; HGNC:11830; TK1; Simple; p.Ala78Argfs*27 (c.231insC); Zygosity=Heterozygous (PubMed=33198927).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Transformant: ChEBI; CHEBI_132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
CC   Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C97074; Hereditary spherocytosis
DI   ORDO; Orphanet_822; Hereditary spherocytosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0561 ! TK6
SX   Male
AG   5Y
CA   Transformed cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=3745200; DOI=10.1016/S0021-9258(18)67110-8;
RA   Goldmacher V.S., Cuzick R.A. Jr., Thilly W.G.;
RT   "Isolation and partial characterization of human cell mutants
RT   differing in sensitivity to killing and mutation by methylnitrosourea
RT   and N-methyl-N'-nitro-N-nitrosoguanidine.";
RL   J. Biol. Chem. 261:12462-12471(1986).
//
RX   PubMed=8341649; DOI=10.1073/pnas.90.14.6424; PMCID=PMC46944;
RA   Kat A.G., Thilly W.G., Fang W.-H., Longley M.J., Li G.-M., Modrich P.L.;
RT   "An alkylation-tolerant, mutator human cell line is deficient in
RT   strand-specific mismatch repair.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:6424-6428(1993).
//
RX   PubMed=18805990; DOI=10.1101/gad.1688508; PMCID=PMC2559901;
RA   Fry R.C., Svensson J.P., Valiathan C., Wang E., Hogan B.J.,
RA   Bhattacharya S., Bugni J.M., Whittaker C.A., Samson L.D.;
RT   "Genomic predictors of interindividual differences in response to DNA
RT   damaging agents.";
RL   Genes Dev. 22:2621-2626(2008).
//