ID   Abcam THP-1 PLCG2 KO
AC   CVCL_E7C2
SY   Human PLCG2 knockout THP-1
DR   Abcam; ab308482
RX   PubMed=39429638;
CC   Population: Japanese.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:9066; PLCG2.
CC   Sequence variation: Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0006 ! THP-1
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=39429638; DOI=10.12688/f1000research.146156.1; PMCID=PMC11489847;
RA   Ruiz Moleon V., Fotouhi M., Alende C., Ayoubi R., Bedford L.M.,
RA   Southern K., Richardson T.I., Laflamme C.;
RG   ABIF Consortium;
RG   NeuroSGC/YCharOS/EDDU Collaborative Group;
RT   "A guide to selecting high-performing antibodies for PLC-gamma-2 for
RT   use in western blot, immunoprecipitation and immunofluorescence.";
RL   F1000Research 13:77.1-77.13(2024).
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