ID   SiHa fat-1
AC   CVCL_E6ZA
SY   f-SiHa
DR   ABM; T6261
RX   DOI=10.1136/esmoopen-2018-EACR25.164;
CC   Population: Japanese.
CC   Characteristics: Applicable for studies investigating the effects of endogenous omega3-polyunsaturated fatty acids (ABM=T6261).
CC   Virology: Contains a complete HPV16 genome with a disruption of the E2 region and a small deletion (from parent cell line).
CC   Doubling time: 30-40 hours (ABM=T6261).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; Q9NEQ0; Caenorhabditis elegans omega-3 fatty acid desaturase fat-1.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0032 ! SiHa
SX   Female
AG   55Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   DOI=10.1136/esmoopen-2018-EACR25.164;
RA   Jing K.-P., Shin S., Lim K.;
RT   "Constitutive expression of FAT1 gene inhibits the invasion and
RT   tumorigenicity of cervical cancer cells through degradation of HPV
RT   E6/E7 oncoprotein via p53/Rb in vitro and in vivo.";
RL   ESMO Open 3 Suppl. 2:A69.P0123-A69.P0123(2018).
//