ID   IEC-Mx2Luc-10
AC   CVCL_E6EK
RX   PubMed=23940817;
CC   Characteristics: Developed from a transgenic mouse that expresses luciferase driven by the promoter of the interferon-stimulated gene Mx2. Tool for the detection of type I and type III IFN responses that recapitulate the in vivo situation and to study the molecular mechanisms of innate immunity of the small intestinal epithelium (PubMed=23940817).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5362; ID3.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6348; KLF4.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Fetal small intestine; UBERON=UBERON_0002108.
CC   Cell type: Epithelial cell of intestine; CL=CL_0002563.
CC   Breed/subspecies: Mx2-Luc transgenic.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   19-20FD
CA   Transformed cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
//
RX   PubMed=23940817; DOI=10.1371/journal.pone.0072700; PMCID=PMC3734307;
RA   Schwerk J., Koster M., Hauser H., Rohde M., Fulde M., Hornef M.W.,
RA   May T.;
RT   "Generation of mouse small intestinal epithelial cell lines that allow
RT   the analysis of specific innate immune functions.";
RL   PLoS ONE 8:e72700.1-e72700.12(2013).
//