ID   BEAS-2B NNKA
AC   CVCL_E6CY
RX   PubMed=1323115;
CC   Characteristics: Very tumorigenic. Derived from xenografts produced by the parent cell line grown in deepithelialized rat tracheas that were subcutaneously transplanted into athymic nude mice and exposed to beeswax pellets containing tobacco-specific N-nitrosamine 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone (NNK) (PubMed=1323115).
CC   Transformant: Ad12-SV40 hybrid virus.
CC   Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
CC   Cell type: Epithelial cell of bronchus; CL=CL_0002328.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0168 ! BEAS-2B
SX   Male
AG   Age unspecified
CA   Transformed cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=1323115; DOI=10.1073/pnas.89.15.6693; PMCID=PMC49569;
RA   Klein-Szanto A.J.P., Iizasa T., Momiki S., Garcia de Palazzo I.E.,
RA   Caamano J., Metcalf R.A., Welsh J.A., Harris C.C.;
RT   "A tobacco-specific N-nitrosamine or cigarette smoke condensate causes
RT   neoplastic transformation of xenotransplanted human bronchial
RT   epithelial cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:6693-6697(1992).
//