ID   ECoM-M
AC   CVCL_E6BD
SY   E2a/Pbx1-mediated Conditional Myeloid-Monocyte
DR   ABM; T0201
RX   PubMed=11588024;
RX   PubMed=12916872;
CC   Characteristics: Exhibits restricted monocytic differentiation. Neutrophil progenitor cells that express a conditional form of TCF3-PBX1 (E2a-Pbx1) in an estrogen responsive manner (PubMed=11588024).
CC   Characteristics: SCF dependent.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3467; ESR1 (Note=With p.Met1_Gly281del and p.Gly400Val in a E2a/Pbx1Delta487-623ER fusion = EPD623ER).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:8632; PBX1 (Note=With p.Met1_Asp232del in a E2a/Pbx1Delta487-623ER fusion = EPD623ER).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11633; TCF3 (Note=With p.Gly484_Met654del in a E2a/Pbx1Delta487-623ER fusion = EPD623ER).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Transformant: TCF3-PBX1 (E2A-PBX1).
CC   Omics: Transcriptomics; Microarray.
CC   Caution: Breed of donor mouse erroneously indicated as being from BALB/c in PubMed=11588024. Correct breed from personal communication of Sykes, David Brian through ABM.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: Mononuclear cell of bone marrow; CL=CL_0010004.
CC   Breed/subspecies: C57BL/6.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Female
AG   Age unspecified
CA   Transformed cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
//
RX   PubMed=11588024; DOI=10.1182/blood.v98.8.2308;
RA   Sykes D.B., Kamps M.P.;
RT   "Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional
RT   differentiation that can be arrested by other leukemic oncoproteins.";
RL   Blood 98:2308-2318(2001).
//
RX   PubMed=12916872; DOI=10.1080/1042819031000090273;
RA   Sykes D.B., Scheele J., Pasillas M.P., Kamps M.P.;
RT   "Transcriptional profiling during the early differentiation of
RT   granulocyte and monocyte progenitors controlled by conditional
RT   versions of the E2a-Pbx1 oncoprotein.";
RL   Leuk. Lymphoma 44:1187-1199(2003).
//