ID   NCH93
AC   CVCL_E5ZE
RX   PubMed=30991738;
RX   PubMed=34885009;
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Lys1491Arg (c.4472A>G); ClinVar=VCV000133474; Zygosity=Unspecified (PubMed=30991738).
CC   Sequence variation: Mutation; HGNC; HGNC:7773; NF2; Simple; p.Asp213fs (c.639delC); Zygosity=Unspecified (PubMed=30991738).
CC   Sequence variation: Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Pro1164Leu (c.3944C>T); ClinVar=VCV000041663; Zygosity=Unspecified (PubMed=30991738).
CC   Derived from site: In situ; Brain, left parieto-occipital lobe.
DI   NCIt; C4051; Anaplastic (malignant) meningioma
DI   ORDO; Orphanet_2495; Meningioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   64Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
//
RX   PubMed=30991738; DOI=10.3390/cancers11040545; PMCID=PMC6521001;
RA   Jungwirth G., Yu T., Moustafa M., Rapp C., Warta R., Jungk C., Sahm F.,
RA   Dettling S., Zweckberger K., Lamszus K., Senft C., Lohr M., Kessler A.F.,
RA   Ketter R., Westphal M., Debus J., von Deimling A., Simon M.,
RA   Unterberg A., Abdollahi A., Herold-Mende C.;
RT   "Identification of KIF11 as a novel target in meningioma.";
RL   Cancers (Basel) 11:545.1-545.18(2019).
//
RX   PubMed=34885009; DOI=10.3390/cancers13235898; PMCID=PMC8657092;
RA   Yu T., Cao J.-G., Alaa Eddine M., Moustafa M., Mock A., Erkut C.,
RA   Abdollahi A., Warta R., Unterberg A., Herold-Mende C., Jungwirth G.;
RT   "Receptor-tyrosine kinase inhibitor ponatinib inhibits meningioma
RT   growth in vitro and in vivo.";
RL   Cancers (Basel) 13:5898.1-5898.16(2021).
//