ID   oTr1
AC   CVCL_E5ZD
SY   oTr-1; Ovine Trophectoderm cell line 1
DR   ABM; T0435
RX   PubMed=18339715;
RX   PubMed=20385232;
RX   PubMed=20844281;
RX   PubMed=27512152;
CC   Derived from site: In situ; Trophectoderm; UBERON=UBERON_0004345.
OX   NCBI_TaxID=9940; ! Ovis aries (Sheep)
SX   Sex unspecified
AG   15FD
CA   Spontaneously immortalized cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=18339715; DOI=10.1210/en.2007-1367;
RA   Kim J.-Y., Song G., Gao H.-J., Farmer J.L., Satterfield M.C.,
RA   Burghardt R.C., Wu G., Johnson G.A., Spencer T.E., Bazer F.W.;
RT   "Insulin-like growth factor II activates phosphatidylinositol
RT   3-kinase-protooncogenic protein kinase 1 and mitogen-activated
RT   protein kinase cell signaling pathways, and stimulates migration of
RT   ovine trophectoderm cells.";
RL   Endocrinology 149:3085-3094(2008).
//
RX   PubMed=20385232; DOI=10.1016/j.matbio.2010.04.001;
RA   Kim J.-Y., Erikson D.W., Burghardt R.C., Spencer T.E., Wu G.-Y.,
RA   Bayless K.J., Johnson G.A., Bazer F.W.;
RT   "Secreted phosphoprotein 1 binds integrins to initiate multiple cell
RT   signaling pathways, including FRAP1/mTOR, to support attachment and
RT   force-generated migration of trophectoderm cells.";
RL   Matrix Biol. 29:369-382(2010).
//
RX   PubMed=20844281; DOI=10.1095/biolreprod.110.085753;
RA   Kim J.-Y., Burghardt R.C., Wu G.-Y., Johnson G.A., Spencer T.E.,
RA   Bazer F.W.;
RT   "Select nutrients in the ovine uterine lumen. VIII. Arginine
RT   stimulates proliferation of ovine trophectoderm cells through
RT   MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and
RT   polyamines.";
RL   Biol. Reprod. 84:70-78(2011).
//
RX   PubMed=27512152; DOI=10.1095/biolreprod.115.137943;
RA   Wang X.-Q., Johnson G.A., Burghardt R.C., Wu G.-Y., Bazer F.W.;
RT   "Uterine histotroph and conceptus development. II. Arginine and
RT   secreted phosphoprotein 1 cooperatively stimulate migration and
RT   adhesion of ovine trophectoderm cells via focal adhesion-MTORC2
RT   mediated cytoskeleton reorganization.";
RL   Biol. Reprod. 95:71.1-71.12(2016).
//