ID   DG-75 CBF1 KO clone SM166C52
AC   CVCL_E5V5
RX   PubMed=15994772;
CC   Population: Jewish; Ashkenazi.
CC   Virology: EBV-negative.
CC   Knockout cell: Method=Homologous recombination; HGNC; HGNC:5724; RBPJ (Note=1 of 3 alleles).
CC   Sequence variation: Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg283His (c.848G>A); ClinVar=VCV000142324; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Homologous recombination; Gene=FPbase; TXLFX; DsRed2 (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
CC   Genetic integration: Method=Homologous recombination; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C2912; Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0244 ! DG-75
SX   Male
AG   10Y
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
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RX   PubMed=15994772; DOI=10.1128/JVI.79.14.8784-8792.2005; PMCID=PMC1168782;
RA   Maier S., Santak M., Mantik A., Grabusic K., Kremmer E.,
RA   Hammerschmidt W., Kempkes B.;
RT   "A somatic knockout of CBF1 in a human B-cell line reveals that
RT   induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and
RT   that downregulation of immunoglobulin M is partially CBF1
RT   independent.";
RL   J. Virol. 79:8784-8792(2005).
//