ID   A2780 RRAS2 KO#3
AC   CVCL_E5L1
RX   PubMed=36476833;
CC   Population: African American.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17271; RRAS2.
CC   Sequence variation: Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
DI   NCIt; C7979; Ovarian endometrioid adenocarcinoma
DI   ORDO; Orphanet_454723; Endometrioid carcinoma of ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0134 ! A2780
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 10-04-25; Last updated: 10-04-25; Version: 1
//
RX   PubMed=36476833; DOI=10.1038/s41388-022-02563-9; PMCID=PMC9883167;
RA   Clavain L., Fernandez-Pisonero M.I., Movilla N., Lorenzo-Martin L.F.,
RA   Nieto B., Abad A., Garcia-Navas R., Llorente-Gonzalez C.,
RA   Sanchez-Martin M., Vicente-Manzanares M., Santos E., Alarcon B.,
RA   Garcia-Aznar J.M., Dosil M., Bustelo X.R.;
RT   "Characterization of mutant versions of the R-RAS2/TC21 GTPase found
RT   in tumors.";
RL   Oncogene 42:389-405(2023).
//