ID   Bx-GEM50
AC   CVCL_E4NF
RX   PubMed=26828016;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_175901; Gemcitabine (Gemzar).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val487_Pro492delinsAla (c.1460_1474delGTGTAGGTGCTGTCA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; None_reported; -; Zygosity=- (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0186 ! BxPC-3
SX   Female
AG   61Y
CA   Cancer cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
//
RX   PubMed=26828016; DOI=10.1016/j.canlet.2016.01.038;
RA   Fan P., Liu L., Yin Y.-F., Zhao Z.-F., Zhang Y.-Y., Amponsah P.S.,
RA   Xiao X., Bauer N., Abukiwan A., Nwaeburu C.C., Gladkich J., Gao C.,
RA   Schemmer P., Gross W., Herr I.;
RT   "MicroRNA-101-3p reverses gemcitabine resistance by inhibition of
RT   ribonucleotide reductase M1 in pancreatic cancer.";
RL   Cancer Lett. 373:130-137(2016).
//