ID   ZR-75-1 IX-6
AC   CVCL_E4L1
SY   ZR-75-1 [IX-6]
DR   CancerTools; 154551
RX   PubMed=8413311;
RX   PubMed=18351453;
CC   Population: Caucasian.
CC   Characteristics: Infected with an amphotropic defective murine retrovirus. Retroviral insertion was used in order to identify genes responsible for estrogen-independence and thus tamoxifen resistant (PubMed=8413311; PubMed=18351453).
CC   Characteristics: Genes likely to be responsible to resistance in this cell line are MAP7 and LOC440474 (unknown gene locus) (PubMed=18351453).
CC   Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0588 ! ZR-75-1
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 19-12-24; Last updated: 10-04-25; Version: 2
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RX   PubMed=8413311; DOI=10.1210/mend.7.7.8413311;
RA   Dorssers L.C.J., van Agthoven T., Dekker A., van Agthoven T.L.A.,
RA   Kok E.M.;
RT   "Induction of antiestrogen resistance in human breast cancer cells by
RT   random insertional mutagenesis using defective retroviruses:
RT   identification of bcar-1, a common integration site.";
RL   Mol. Endocrinol. 7:870-878(1993).
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RX   PubMed=18351453; DOI=10.1007/s10549-008-9969-5;
RA   van Agthoven T., Veldscholte J.W., Smid M., van Agthoven T.L.A.,
RA   Vreede L., Broertjes M., de Vries I., de Jong D., Sarwari R.,
RA   Dorssers L.C.J.;
RT   "Functional identification of genes causing estrogen independence of
RT   human breast cancer cells.";
RL   Breast Cancer Res. Treat. 114:23-30(2009).
//