ID   NCI-H69/IL2/IFN-gamma
AC   CVCL_E4CR
RX   PubMed=9415308;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:5438; IFNG.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6001; IL2.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E4CQ ! NCI-H69/IL2
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 19-12-24; Last updated: 10-04-25; Version: 2
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RX   PubMed=9415308; DOI=10.1038/sj.gt.3300489;
RA   Traversari C., Meazza R., Coppolecchia M., Basso S., Verrecchia A.,
RA   van der Bruggen P., Ardizzoni A., Gaggero A., Ferrini S.;
RT   "IFN-gamma gene transfer restores HLA-class I expression and MAGE-3
RT   antigen presentation to CTL in HLA-deficient small cell lung cancer.";
RL   Gene Ther. 4:1029-1035(1997).
//