ID   1BR3-hTERT PBRM1 KO 5 + PBRM1
AC   CVCL_E3WE
SY   1BR3 PBRM1 KO5 + PBRM1
DR   CancerTools; 161870
RX   PubMed=35902118;
CC   Characteristics: PBRM1 is expressed upon doxycycline induction (PubMed=35902118).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:30064; PBRM1.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:30064; PBRM1.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E3VD ! 1BR3-hTERT PBRM1 KO 5
SX   Male
AG   23Y
CA   Telomerase immortalized cell line
DT   Created: 19-12-24; Last updated: 19-12-24; Version: 1
//
RX   PubMed=35902118; DOI=10.1101/gad.349249.121; PMCID=PMC9480851;
RA   Feng H.-G., Lane K.A., Roumeliotis T.I., Jeggo P.A., Somaiah N.,
RA   Choudhary J.S., Downs J.A.;
RT   "PBAF loss leads to DNA damage-induced inflammatory signaling through
RT   defective G2/M checkpoint maintenance.";
RL   Genes Dev. 36:790-806(2022).
//