ID   Immortalized primary brown preadipocytes Irs1 KO
AC   CVCL_E3FP
RX   PubMed=11113206;
RX   PubMed=11948624;
CC   Knockout cell: Method=KO mouse; MGI; MGI:99454; Irs1.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Brown adipose tissue; UBERON=UBERON_0001348.
CC   Cell type: Preadipocyte; CL=CL_0002334.
CC   Breed/subspecies: Irs1-/-.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   1D
CA   Transformed cell line
DT   Created: 19-12-24; Last updated: 14-08-25; Version: 3
//
RX   PubMed=11113206; DOI=10.1128/mcb.21.1.319-329.2001; PMCID=PMC88805;
RA   Fasshauer, Mathias
RA   Klein, Johannes
RA   Kriauciunas, Kristina M.
RA   Ueki, Kohjiro
RA   Benito, Manuel
RA   Kahn, Carl Ronald
RT   "Essential role of insulin receptor substrate 1 in differentiation of
RT   brown adipocytes.";
RL   Mol. Cell. Biol. 21:319-329(2001).
//
RX   PubMed=11948624; DOI=10.1002/bies.10058;
RA   Klein, Johannes
RA   Fasshauer, Mathias
RA   Klein, Harald Horst
RA   Benito, Manuel
RA   Kahn, Carl Ronald
RT   "Novel adipocyte lines from brown fat: a model system for the study of
RT   differentiation, energy metabolism, and insulin action.";
RL   Bioessays 24:382-388(2002).
//