ID   MSA-5 pB-rtTA(#4)-NGN2-puro-SNAP
AC   CVCL_E3D0
RX   PubMed=39079530;
CC   Part of: Mass General Brigham Stem Cells in Neurodegeneration [SCiN] panel.
CC   Characteristics: Transposed with a piggyBac-rtTA(TRE4G)-NGN2-T2A-PuroR-IRES-SNAP-tag construct (PubMed=39079530).
CC   Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:7059; MGMT (Note=With p.Gly180_Asn207del and 19 mutations = SNAP-tag).
CC   Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:13805; NEUROG2.
CC   Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Ankle, skin; UBERON=UBERON_0001512.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C84909; Multiple system atrophy
DI   ORDO; Orphanet_102; Multiple system atrophy
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E3CP ! MSA-5
SX   Female
AG   60Y
CA   Induced pluripotent stem cell
DT   Created: 10-09-24; Last updated: 10-04-25; Version: 3
//
RX   PubMed=39079530; DOI=10.1016/j.neuron.2024.06.002; PMCID=PMC11377155;
RA   Lam I., Ndayisaba A., Lewis A.J., Fu Y.-H., Sagredo G.T., Kuzkina A.,
RA   Zaccagnini L., Celikag M., Sandoe J., Sanz R.L., Vahdatshoar A.,
RA   Martin T.D., Morshed N., Ichihashi T., Tripathi A., Ramalingam N.,
RA   Oettgen-Suazo C., Bartels T., Boussouf M., Schabinger M., Hallacli E.,
RA   Jiang X., Verma A., Tea C., Wang Z.-C., Hakozaki H., Yu X., Hyles K.,
RA   Park C., Wang X.-Y., Theunissen T.W., Wang H.-Y., Jaenisch R.,
RA   Lindquist S.L., Stevens B., Stefanova N., Wenning G.K., van de Berg W.D.J.,
RA   Luk K.C., Sanchez-Pernaute R., Gomez-Esteban J.C., Felsky D., Kiyota Y.,
RA   Sahni N., Yi S.S., Chung C.-Y., Stahlberg H., Ferrer I., Schoneberg J.,
RA   Elledge S.J., Dettmer U., Halliday G.M., Bartels T., Khurana V.;
RT   "Rapid iPSC inclusionopathy models shed light on formation,
RT   consequence, and molecular subtype of alpha-synuclein inclusions.";
RL   Neuron 112:2886-2909.e16(2024).
//