ID   HT93A
AC   CVCL_E331
SY   HT-93A; HT-93; HT93
DR   Cosmic; 975254
DR   Cosmic; 1281317
DR   DSMZ; ACC-735
DR   DSMZCellDive; ACC-735
DR   TKG; TKG 0703
DR   Wikidata; Q54896599
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8690048;
RX   PubMed=9472803;
RX   PubMed=10706884;
RX   PubMed=25373509;
CC   Population: Japanese.
CC   Doubling time: ~48 hours (PubMed=9472803); ~50 hours (DSMZ=ACC-735).
CC   Sequence variation: Gene fusion; HGNC; 77; ABL2 + HGNC; 3495; ETV6; Name(s)=ETV6-ABL2, ETV6-ARG (PubMed=10706884).
CC   Sequence variation: Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (PubMed=9472803).
CC   Derived from sampling site: Peripheral blood.
ST   Source(s): DSMZ; TKG
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 9,12
ST   D16S539: 9,11
ST   D18S51: 9,13
ST   D19S433: 13,14
ST   D21S11: 29,32.2
ST   D2S1338: 24
ST   D3S1358: 15,17
ST   D5S818: 10,13
ST   D7S820: 11,12
ST   D8S1179: 14,15
ST   FGA: 21
ST   Penta D: 9,11
ST   Penta E: 16,18
ST   TH01: 7
ST   TPOX: 8,11
ST   vWA: 14,18
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   66Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 21-03-23; Version: 18
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
RX   PubMed=8690048;
RA   Toba K., Kishi K., Koike T., Winton E.F., Takahashi H., Nagai K.,
RA   Maruyama S., Furukawa T., Hashimoto S., Masuko M., Uesugi Y.,
RA   Kuroha T., Tsukada N., Shibata A.;
RT   "Profile of cell cycle in hematopoietic malignancy by DNA/RNA
RT   quantitation using 7AAD/PY.";
RL   Exp. Hematol. 24:894-901(1996).
RX   PubMed=9472803;
RA   Kishi K., Toba K., Azegami T., Tsukada N., Uesugi Y., Masuko M.,
RA   Niwano H., Hashimoto S., Sakaue M., Furukawa T., Koike T.,
RA   Takahashi H., Maekawa T., Abe T., Aizawa Y.;
RT   "Hematopoietic cytokine-dependent differentiation to eosinophils and
RT   neutrophils in a newly established acute promyelocytic leukemia cell
RT   line with t(15;17).";
RL   Exp. Hematol. 26:135-142(1998).
RX   PubMed=10706884; DOI=10.1182/blood.V95.6.2126;
RA   Iijima Y., Ito T., Oikawa T., Eguchi M., Eguchi-Ishimae M., Kamada N.,
RA   Kishi K., Asano S., Sakaki Y., Sato Y.;
RT   "A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2),
RT   identified in an AML-M3 cell line with a t(1;12)(q25;p13)
RT   translocation.";
RL   Blood 95:2126-2131(2000).
RX   PubMed=25373509; DOI=10.3109/10428194.2014.982643;
RA   Iriyama N., Hatta Y., Takei M.;
RT   "ETV6/ARG oncoprotein confers autonomous cell growth by enhancing
RT   c-Myc expression via signal transducer and activator of transcription
RT   5 activation in the acute promyelocytic leukemia cell line HT93A.";
RL   Leuk. Lymphoma 56:2416-2423(2015).