ID   HT93A
AC   CVCL_E331
SY   HT-93A; HT-93; HT93
DR   Cosmic; 975254
DR   Cosmic; 1281317
DR   DSMZ; ACC-735
DR   DSMZCellDive; ACC-735
DR   TKG; TKG 0703
DR   Wikidata; Q54896599
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8690048;
RX   PubMed=9472803;
RX   PubMed=10706884;
RX   PubMed=25373509;
RX   PubMed=36982453;
CC   Population: Japanese.
CC   Doubling time: ~48 hours (PubMed=9472803); ~50 hours (DSMZ=ACC-735).
CC   Sequence variation: Gene fusion; HGNC; HGNC:77; ABL2 + HGNC; HGNC:3495; ETV6; Name(s)=ETV6-ABL2, ETV6-ARG (PubMed=10706884).
CC   Sequence variation: Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (PubMed=9472803).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DSMZ=ACC-735; TKG=TKG 0703
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 9,12
ST   D16S539: 9,11
ST   D18S51: 9,13
ST   D19S433: 13,14
ST   D21S11: 29,32.2
ST   D2S1338: 24
ST   D3S1358: 15,17
ST   D5S818: 10,13
ST   D7S820: 11,12
ST   D8S1179: 14,15
ST   FGA: 21
ST   Penta D: 9,11
ST   Penta E: 16,18
ST   TH01: 7
ST   TPOX: 8,11
ST   vWA: 14,18
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   66Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 14-08-25; Version: 22
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=9472803;
RA   Kishi, Kenji
RA   Toba, Ken
RA   Azegami, Taka-aki
RA   Tsukada, Nobuhiro
RA   Uesugi, Yumiko
RA   Masuko, Masayoshi
RA   Niwano, Hiroe
RA   Hashimoto, Shigeo
RA   Sakaue, Minori
RA   Furukawa, Tatsuo
RA   Koike, Tadashi
RA   Takahashi, Hoyu
RA   Maekawa, Taira
RA   Abe, Tatsuo
RA   Aizawa, Yoshifusa
RT   "Hematopoietic cytokine-dependent differentiation to eosinophils and
RT   neutrophils in a newly established acute promyelocytic leukemia cell
RT   line with t(15;17).";
RL   Exp. Hematol. 26:135-142(1998).
//
RX   PubMed=8690048;
RA   Toba, Ken
RA   Kishi, Kenji
RA   Koike, Tadashi
RA   Winton, Elliott F.
RA   Takahashi, Hoyu
RA   Nagai, Koichi
RA   Maruyama, Soichi
RA   Furukawa, Tatsuo
RA   Hashimoto, Shigeo
RA   Masuko, Masayoshi
RA   Uesugi, Yumiko
RA   Kuroha, Takashi
RA   Tsukada, Nobuhiro
RA   Shibata, Akira
RT   "Profile of cell cycle in hematopoietic malignancy by DNA/RNA
RT   quantitation using 7AAD/PY.";
RL   Exp. Hematol. 24:894-901(1996).
//
RX   PubMed=10706884; DOI=10.1182/blood.V95.6.2126;
RA   Iijima, Yoshimi
RA   Ito, Takashi
RA   Oikawa, Tsuneyuki
RA   Eguchi, Mariko
RA   Eguchi-Ishimae, Minenori
RA   Kamada, Nanao
RA   Kishi, Kenji
RA   Asano, Shigetaka
RA   Sakaki, Yoshiyuki
RA   Sato, Yuko
RT   "A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2),
RT   identified in an AML-M3 cell line with a t(1;12)(q25;p13)
RT   translocation.";
RL   Blood 95:2126-2131(2000).
//
RX   PubMed=25373509; DOI=10.3109/10428194.2014.982643;
RA   Iriyama, Noriyoshi
RA   Hatta, Yoshihiro
RA   Takei, Masami
RT   "ETV6/ARG oncoprotein confers autonomous cell growth by enhancing
RT   c-Myc expression via signal transducer and activator of transcription
RT   5 activation in the acute promyelocytic leukemia cell line HT93A.";
RL   Leuk. Lymphoma 56:2416-2423(2015).
//
RX   PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680;
RA   Skopek, Rafal
RA   Palusinska, Malgorzata
RA   Kaczor-Keller, Katarzyna
RA   Pingwara, Rafal
RA   Papierniak-Wygladala, Anna
RA   Schenk, Tino
RA   Lewicki, Slawomir
RA   Zelent, Artur
RA   Szymanski, Lukasz
RT   "Choosing the right cell line for acute myeloid leukemia (AML)
RT   research.";
RL   Int. J. Mol. Sci. 24:5377.1-5377.34(2023).
//