ID   HT93A
AC   CVCL_E331
SY   HT-93A; HT-93; HT93
DR   Cosmic; 975254
DR   Cosmic; 1281317
DR   DSMZ; ACC-735
DR   DSMZCellDive; ACC-735
DR   TKG; TKG 0703
DR   Wikidata; Q54896599
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8690048;
RX   PubMed=9472803;
RX   PubMed=10706884;
RX   PubMed=25373509;
CC   Population: Japanese.
CC   Doubling time: ~48 hours (PubMed=9472803); ~50 hours (DSMZ=ACC-735).
CC   Sequence variation: Gene fusion; HGNC; HGNC:77; ABL2 + HGNC; HGNC:3495; ETV6; Name(s)=ETV6-ABL2, ETV6-ARG (PubMed=10706884).
CC   Sequence variation: Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (PubMed=9472803).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DSMZ=ACC-735; TKG=TKG 0703
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 9,12
ST   D16S539: 9,11
ST   D18S51: 9,13
ST   D19S433: 13,14
ST   D21S11: 29,32.2
ST   D2S1338: 24
ST   D3S1358: 15,17
ST   D5S818: 10,13
ST   D7S820: 11,12
ST   D8S1179: 14,15
ST   FGA: 21
ST   Penta D: 9,11
ST   Penta E: 16,18
ST   TH01: 7
ST   TPOX: 8,11
ST   vWA: 14,18
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   66Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 21
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=8690048;
RA   Toba K., Kishi K., Koike T., Winton E.F., Takahashi H., Nagai K.,
RA   Maruyama S., Furukawa T., Hashimoto S., Masuko M., Uesugi Y.,
RA   Kuroha T., Tsukada N., Shibata A.;
RT   "Profile of cell cycle in hematopoietic malignancy by DNA/RNA
RT   quantitation using 7AAD/PY.";
RL   Exp. Hematol. 24:894-901(1996).
//
RX   PubMed=9472803;
RA   Kishi K., Toba K., Azegami T.-a., Tsukada N., Uesugi Y., Masuko M.,
RA   Niwano H., Hashimoto S., Sakaue M., Furukawa T., Koike T.,
RA   Takahashi H., Maekawa T., Abe T., Aizawa Y.;
RT   "Hematopoietic cytokine-dependent differentiation to eosinophils and
RT   neutrophils in a newly established acute promyelocytic leukemia cell
RT   line with t(15;17).";
RL   Exp. Hematol. 26:135-142(1998).
//
RX   PubMed=10706884; DOI=10.1182/blood.V95.6.2126;
RA   Iijima Y., Ito T., Oikawa T., Eguchi M., Eguchi-Ishimae M., Kamada N.,
RA   Kishi K., Asano S., Sakaki Y., Sato Y.;
RT   "A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2),
RT   identified in an AML-M3 cell line with a t(1;12)(q25;p13)
RT   translocation.";
RL   Blood 95:2126-2131(2000).
//
RX   PubMed=25373509; DOI=10.3109/10428194.2014.982643;
RA   Iriyama N., Hatta Y., Takei M.;
RT   "ETV6/ARG oncoprotein confers autonomous cell growth by enhancing
RT   c-Myc expression via signal transducer and activator of transcription
RT   5 activation in the acute promyelocytic leukemia cell line HT93A.";
RL   Leuk. Lymphoma 56:2416-2423(2015).
//