ID   HKCI-1
AC   CVCL_E308
DR   cancercelllines; CVCL_E308
DR   Wikidata; Q54889748
RX   PubMed=10958934;
RX   PubMed=11793441;
RX   PubMed=15645427;
RX   PubMed=15709204;
RX   PubMed=19003983;
RX   PubMed=24582836;
CC   Population: Chinese.
CC   Doubling time: ~60 hours (PubMed=10958934).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Unspecified (PubMed=10958934).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Caution: Indicated as originating from a 44 year old male in material methods of PubMed=10958934 and from a 58 year old male in table 1 of the same publication.
CC   Misspelling: HCKI-1; PubMed=10958934; Note=In table 1.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   44Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 16
//
RX   PubMed=10958934; DOI=10.1016/S0165-4608(99)00247-2;
RA   Pang E., Wong N., Lai P.B.-S., To K.-F., Lau J.W.-Y., Johnson P.J.;
RT   "A comprehensive karyotypic analysis on a newly developed
RT   hepatocellular carcinoma cell line, HKCI-1, by spectral karyotyping
RT   and comparative genomic hybridization.";
RL   Cancer Genet. Cytogenet. 121:9-16(2000).
//
RX   PubMed=11793441; DOI=10.1002/gcc.1220;
RA   Pang E., Wong N., Lai P.B.-S., To K.-F., Lau J.W.-Y., Johnson P.J.;
RT   "Consistent chromosome 10 rearrangements in four newly established
RT   human hepatocellular carcinoma cell lines.";
RL   Genes Chromosomes Cancer 33:150-159(2002).
//
RX   PubMed=15645427; DOI=10.1002/ijc.20684;
RA   Chan K.Y.-Y., Wong N., Lai P.B.-S., Squire J.A., Macgregor P.F.,
RA   Beheshti B., Albert M., To K.-F., Johnson P.J.;
RT   "Transcriptional profiling on chromosome 19p indicated frequent
RT   downregulation of ACP5 expression in hepatocellular carcinoma.";
RL   Int. J. Cancer 114:902-908(2005).
//
RX   PubMed=15709204; DOI=10.1158/1078-0432.1319.11.3;
RA   Wong N., Chan K.Y.-Y., Macgregor P.F., Lai P.B.-S., Squire J.A.,
RA   Beheshti B., Albert M., Leung T.W.-T.;
RT   "Transcriptional profiling identifies gene expression changes
RT   associated with IFN-alpha tolerance in hepatitis C-related
RT   hepatocellular carcinoma cells.";
RL   Clin. Cancer Res. 11:1319-1326(2005).
//
RX   PubMed=19003983; DOI=10.1002/ijc.23968;
RA   Wong N., Yeo W., Wong W.-L., Wong N.L.-Y., Chan K.Y.-Y., Mo F.K.-F.,
RA   Koh J., Chan S.L., Chan A.T.-C., Lai P.B.-S., Ching A.K.-K.,
RA   Tong J.H.-M., Ng H.-K., Johnson P.J., To K.-F.;
RT   "TOP2A overexpression in hepatocellular carcinoma correlates with
RT   early age onset, shorter patients survival and chemoresistance.";
RL   Int. J. Cancer 124:644-652(2009).
//
RX   PubMed=24582836; DOI=10.1016/j.ccr.2014.01.030;
RA   Lau C.-C., Sun T.-T., Ching A.K.-K., He M., Li J.-W., Wong A.M., Co N.N.,
RA   Chan A.W.-H., Li P.-S., Lung R.W.-M., Tong J.H.-M., Lai P.B.-S.,
RA   Chan H.L.-Y., To K.-F., Chan T.-F., Wong N.;
RT   "Viral-human chimeric transcript predisposes risk to liver cancer
RT   development and progression.";
RL   Cancer Cell 25:335-349(2014).
//