ID   MDAH041
AC   CVCL_E212
SY   MDAH 041; 041S
DR   Wikidata; Q54904670
RX   PubMed=2000218;
RX   PubMed=2253239;
RX   PubMed=3111682;
RX   PubMed=7667317;
DI   NCIt; C3476; Li-Fraumeni syndrome
DI   ORDO; Orphanet_524; Li-Fraumeni syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   22Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 12-03-20; Version: 8
RX   PubMed=2000218;
RA   Bischoff F.Z., Strong L.C., Yim S.O., Pratt D.R., Siciliano M.J.,
RA   Giovanella B.C., Tainsky M.A.;
RT   "Tumorigenic transformation of spontaneously immortalized fibroblasts
RT   from patients with a familial cancer syndrome.";
RL   Oncogene 6:183-186(1991).
RX   PubMed=2253239;
RA   Bischoff F.Z., Yim S.O., Pathak S., Grant G., Siciliano M.J.,
RA   Giovanella B.C., Strong L.C., Tainsky M.A.;
RT   "Spontaneous abnormalities in normal fibroblasts from patients with
RT   Li-Fraumeni cancer syndrome: aneuploidy and immortalization.";
RL   Cancer Res. 50:7979-7984(1990).
RX   PubMed=3111682;
RA   Little J.B., Nove J., Dahlberg W.K., Troilo P., Nichols W.W.,
RA   Strong L.C.;
RT   "Normal cytotoxic response of skin fibroblasts from patients with
RT   Li-Fraumeni familial cancer syndrome to DNA-damaging agents in
RT   vitro.";
RL   Cancer Res. 47:4229-4234(1987).
RX   PubMed=7667317; DOI=10.1073/pnas.92.18.8493;
RA   Agarwal M.L., Agarwal A., Taylor W.R., Stark G.R.;
RT   "p53 controls both the G2/M and the G1 cell cycle checkpoints and
RT   mediates reversible growth arrest in human fibroblasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:8493-8497(1995).