ID   HyCyte SK-HEP-1 KO-hPFDN2
AC   CVCL_E1MV
SY   hPFDN2 knockout SK-HEP-1
DR   Hysigen; CGKO-M2610
CC   Problematic cell line: Misclassified. Parent cell line (SK-HEP-1) was originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells.
CC   Population: Caucasian.
CC   Doubling time: 24-48 hours (Hysigen=CGKO-M2610).
CC   Karyotypic information: Has lost chromosome Y (from parent cell line).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:8867; PFDN2.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Endothelial cell; CL=CL_0000115.
DI   NCIt; C7106; Liver and intrahepatic bile duct epithelial neoplasm
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0525 ! SK-HEP-1
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 19-12-24; Version: 2
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