ID   WA26
AC   CVCL_E081
SY   WAe026-A
DR   hPSCreg; WAe026-A
DR   ISCR; 2021
DR   NIHhESC; NIHhESC-12-0197
DR   WiCell; wa26
DR   Wikidata; Q54993533
RX   PubMed=28445466;
WW   https://www.wicell.org/media/Ads/2013.ISSCR.DerivationFinal.pdf
CC   Group: Clinical grade pluripotent cell line.
CC   From: University of Wisconsin; Madison; USA.
CC   Registration: NIH Human Embryonic Stem Cell Registry; NIHhESC-12-0197.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Unspecified; Note=Somatic mutation acquired during proliferation (PubMed=28445466).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
ST   Source(s): WiCell=wa26
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11,12
ST   D16S539: 12,14
ST   D5S818: 12
ST   D7S820: 10
ST   TH01: 7,10
ST   TPOX: 8,11
ST   vWA: 17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 22-10-12; Last updated: 02-05-24; Version: 21
//
RX   PubMed=28445466; DOI=10.1038/nature22312;
RA   Merkle F.T., Ghosh S., Kamitaki N., Mitchell J., Avior Y., Mello C.,
RA   Kashin S., Mekhoubad S., Ilic D., Charlton M., Saphier G.,
RA   Handsaker R.E., Genovese G., Bar S., Benvenisty N., McCarroll S.A.,
RA   Eggan K.C.;
RT   "Human pluripotent stem cells recurrently acquire and expand dominant
RT   negative P53 mutations.";
RL   Nature 545:229-233(2017).
//