ID   RCC6 [France]
AC   CVCL_E056
SY   RCC-6
DR   cancercelllines; CVCL_E056
DR   Cosmic; 1497326
DR   Wikidata; Q54949469
RX   PubMed=12351398;
RX   PubMed=15661891;
RX   PubMed=21258414;
CC   HLA typing: A*01,02; B*08,51; C*w07,w14 (PubMed=12351398).
CC   Sequence variation: Mutation; HGNC; HGNC:12687; VHL; Simple; p.Ser111Gly (c.331A>G); ClinVar=VCV000633016; Zygosity=Hemizygous (PubMed=21258414).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 12
//
RX   PubMed=12351398; DOI=10.1182/blood-2002-02-0643;
RA   Guerra N., Michel F., Gati A., Gaudin C., Mishal Z., Escudier B.J.,
RA   Acuto O., Chouaib S., Caignard A.;
RT   "Engagement of the inhibitory receptor CD158a interrupts TCR
RT   signaling, preventing dynamic membrane reorganization in CTL/tumor
RT   cell interaction.";
RL   Blood 100:2874-2881(2002).
//
RX   PubMed=15661891; DOI=10.4049/jimmunol.174.3.1338;
RA   Viey E., Fromont G., Escudier B.J., Morel Y., Da Rocha S., Chouaib S.,
RA   Caignard A.;
RT   "Phosphostim-activated gamma delta T cells kill autologous metastatic
RT   renal cell carcinoma.";
RL   J. Immunol. 174:1338-1347(2005).
//
RX   PubMed=21258414; DOI=10.1038/onc.2010.638;
RA   Perier A., Fregni G., Wittnebel S., Gad S., Allard M.,
RA   Gervois-Segain N., Escudier B.J., Azzarone B., Caignard A.;
RT   "Mutations of the von Hippel-Lindau gene confer increased
RT   susceptibility to natural killer cells of clear-cell renal cell
RT   carcinoma.";
RL   Oncogene 30:2622-2632(2011).
//