ID   PC-9/GR3
AC   CVCL_DI30
SY   PC-9 GR3; PC9-GR3
DR   cancercelllines; CVCL_DI30
DR   GEO; GSM481163
DR   GEO; GSM1960272
DR   GEO; GSM1960273
DR   GEO; GSM1960274
DR   GEO; GSM1960275
DR   Progenetix; CVCL_DI30
DR   Wikidata; Q54938496
RX   PubMed=20118985;
RX   PubMed=26828195;
CC   Population: Chinese; Han and Japanese.
CC   Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Unspecified; Note=Responsible for gefitinib resistance (PubMed=20118985).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_B260 ! PC-9
SX   Male
AG   45Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 10-04-25; Version: 16
//
RX   PubMed=20118985; DOI=10.1038/onc.2009.526; PMCID=PMC2859699;
RA   Ercan D., Zejnullahu K., Yonesaka K., Xiao Y., Capelletti M.,
RA   Rogers A., Lifshits E., Brown A., Lee C., Christensen J.G.,
RA   Kwiatkowski D.J., Engelman J.A., Janne P.A.;
RT   "Amplification of EGFR T790M causes resistance to an irreversible EGFR
RT   inhibitor.";
RL   Oncogene 29:2346-2356(2010).
//
RX   PubMed=26828195; DOI=10.1038/nm.4040; PMCID=PMC4900892;
RA   Hata A.N., Niederst M.J., Archibald H.L., Gomez-Caraballo M.,
RA   Siddiqui F.M., Mulvey H.E., Maruvka Y.E., Ji F., Bhang H.-e.C.,
RA   Krishnamurthy Radhakrishna V., Siravegna G., Hu H.-C., Raoof S.,
RA   Lockerman E.L., Kalsy A., Lee D., Keating C.L., Ruddy D.A., Damon L.J.,
RA   Crystal A.S., Costa C., Piotrowska Z., Bardelli A., Iafrate A.J.,
RA   Sadreyev R.I., Stegmeier F., Getz G., Sequist L.V., Faber A.C.,
RA   Engelman J.A.;
RT   "Tumor cells can follow distinct evolutionary paths to become
RT   resistant to epidermal growth factor receptor inhibition.";
RL   Nat. Med. 22:262-269(2016).
//