ID   D28
AC   CVCL_DH69
DR   cancercelllines; CVCL_DH69
DR   Cosmic; 2465280
DR   GEO; GSM170588
DR   GEO; GSM218518
DR   Progenetix; CVCL_DH69
DR   Wikidata; Q54817201
RX   PubMed=17363583;
RX   PubMed=17516929;
RX   PubMed=22383533;
RX   PubMed=23890154;
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Lys (c.1798_1799delGTinsAA); ClinVar=VCV000375941; Zygosity=Heterozygous (PubMed=17363583; PubMed=22383533; PubMed=23890154).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Pro114Leu (c.341C>T) (p.Ala128Ala, c.384C>T); ClinVar=VCV000077637; Zygosity=Unspecified (PubMed=17363583).
CC   Sequence variation: Mutation; HGNC; HGNC:6840; MAP2K1; Simple; p.Pro124Leu (c.371C>T); ClinVar=VCV000040744; Zygosity=Heterozygous (PubMed=22383533).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   66Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 10-04-25; Version: 11
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RX   PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152;
RA   Stark M.S., Hayward N.K.;
RT   "Genome-wide loss of heterozygosity and copy number analysis in
RT   melanoma using high-density single-nucleotide polymorphism arrays.";
RL   Cancer Res. 67:2632-2642(2007).
//
RX   PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x;
RA   Johansson P., Pavey S., Hayward N.K.;
RT   "Confirmation of a BRAF mutation-associated gene expression signature
RT   in melanoma.";
RL   Pigment Cell Res. 20:216-221(2007).
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RX   PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676;
RA   Dutton-Regester K., Irwin D., Hunt P., Aoude L.G., Tembe V.,
RA   Pupo G.M., Lanagan C., Carter C.D., O'Connor L., O'Rourke M.,
RA   Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.;
RT   "A high-throughput panel for identifying clinically relevant mutation
RT   profiles in melanoma.";
RL   Mol. Cancer Ther. 11:888-897(2012).
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RX   PubMed=23890154; DOI=10.1111/pcmr.12153;
RA   Dutton-Regester K., Kakavand H., Aoude L.G., Stark M.S.,
RA   Gartside M.G., Johansson P., O'Connor L., Lanagan C., Tembe V.,
RA   Pupo G.M., Haydu L.E., Schmidt C.W., Mann G.J., Thompson J.F.,
RA   Scolyer R.A., Hayward N.K.;
RT   "Melanomas of unknown primary have a mutation profile consistent with
RT   cutaneous sun-exposed melanoma.";
RL   Pigment Cell Melanoma Res. 26:852-860(2013).
//