ID   SVpgC2a
AC   CVCL_DG34
DR   GEO; GSM190619
DR   GEO; GSM190620
DR   GEO; GSM298193
DR   GEO; GSM966935
DR   GEO; GSM966936
DR   GEO; GSM966937
DR   Wikidata; Q54971035
RX   CelloPub=CLPUB00346;
RX   PubMed=7586160;
RX   PubMed=11377230;
RX   PubMed=15651925;
RX   PubMed=18186669;
RX   PubMed=19287496;
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Oral cavity, buccal mucosa; UBERON=UBERON_0006956.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 13-07-16; Last updated: 10-04-25; Version: 7
//
RX   CelloPub=CLPUB00346;
RA   Ceder R.;
RT   "Cancer biomarker discovery by in vitro systems biology.";
RL   Thesis PhD (2011); Karolinska Institutet; Stockholm; Sweden.
//
RX   PubMed=7586160; DOI=10.1093/carcin/16.10.2515;
RA   Kulkarni P.S., Sundqvist K., Betsholtz C., Hoglund P., Wiman K.G.,
RA   Zhivotovsky B., Bertolero F., Liu Y., Grafstrom R.C.;
RT   "Characterization of human buccal epithelial cells transfected with
RT   the simian virus 40 T-antigen gene.";
RL   Carcinogenesis 16:2515-2521(1995).
//
RX   PubMed=11377230; DOI=10.1016/S1368-8375(00)00089-0;
RA   Hansson A., Bloor B.K., Haig Y., Morgan P.R., Ekstrand J.,
RA   Grafstrom R.C.;
RT   "Expression of keratins in normal, immortalized and malignant oral
RT   epithelia in organotypic culture.";
RL   Oral Oncol. 37:419-430(2001).
//
RX   PubMed=15651925; DOI=10.1177/026119290403200412;
RA   Staab C.A., Vondracek M., Custodio H., Johansson K., Nilsson J.A.,
RA   Morgan P., Hoog J.-O., Cotgreave I.A., Grafstrom R.C.;
RT   "Modelling of normal and premalignant oral tissue by using the
RT   immortalised cell line, SVpgC2a: a review of the value of the model.";
RL   Altern. Lab. Anim. 32:401-405(2004).
//
RX   PubMed=18186669; DOI=10.1177/026119290703500603;
RA   Ceder R., Merne M., Staab C.A., Nilsson J.A., Hoog J.-O., Dressler D.,
RA   Engelhart K., Grafstrom R.C.;
RT   "The application of normal, SV40 T-antigen-immortalised and
RT   tumour-derived oral keratinocytes, under serum-free conditions, to the
RT   study of the probability of cancer progression as a result of
RT   environmental exposure to chemicals.";
RL   Altern. Lab. Anim. 35:621-639(2007).
//
RX   PubMed=19287496; DOI=10.1371/journal.pone.0004849; PMCID=PMC2654098;
RA   Gemenetzidis E., Bose A., Riaz A.M., Chaplin T., Young B.D., Ali M.,
RA   Sugden D., Thurlow J.K., Cheong S.-C., Teo S.-H., Wan H., Waseem A.,
RA   Parkinson E.K., Fortune F., Teh M.-T.;
RT   "FOXM1 upregulation is an early event in human squamous cell carcinoma
RT   and it is enhanced by nicotine during malignant transformation.";
RL   PLoS ONE 4:e4849.1-e4849.18(2009).
//