ID   MDCK 9B9-1E4
AC   CVCL_DF70
SY   MDCK9B9-1E4
DR   Wikidata; Q54904762
RX   Patent=US8846032;
RX   PubMed=20307595;
RX   PubMed=22902973;
CC   Group: Patented cell line.
CC   Group: Vaccine production cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-7910.
CC   Characteristics: Not tumorigenic. Highly permissive to the live attenuated influenza vaccine (LAIV) components.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_0422 ! MDCK
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 13-07-16; Last updated: 10-09-24; Version: 11
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RX   Patent=US8846032;
RA   Liu, Jonathan
RA   Schwartz, Richard
RA   Thompson, Mark
RA   Maranga, Luis
RA   Ghosh, Mridul
RA   Subramanian, Ajit
RA   Hsu, Simon Sheng-Tsiung
RT   "MDCK cell lines supporting viral growth to high titers and bioreactor
RT   process using the same.";
RL   Patent number US8846032, 30-Sep-2014.
//
RX   PubMed=20307595; DOI=10.1016/j.vaccine.2010.03.005; PMCID=PMC7172923;
RA   Hussain, Althaf I.
RA   Cordeiro, Melissa
RA   Sevilla, Elizabeth
RA   Liu, Jonathan
RT   "Comparison of egg and high yielding MDCK cell-derived live attenuated
RT   influenza virus for commercial production of trivalent influenza
RT   vaccine: in vitro cell susceptibility and influenza virus replication
RT   kinetics in permissive and semi-permissive cells.";
RL   Vaccine 28:3848-3855(2010).
//
RX   PubMed=22902973; DOI=10.1016/j.biologicals.2012.06.005;
RA   Vepachedu, Ramarao S.
RA   Menon, Amritha
RA   Hussain, Althaf I.
RA   Liu, Jonathan
RT   "Evaluation of tumorigenic potential of high yielding cloned MDCK
RT   cells for live-attenuated influenza vaccine using in vitro growth
RT   characteristics, metastatic gene expression and in vivo nude mice
RT   model.";
RL   Biologicals 40:482-494(2012).
//