ID   MDCK 9B9-1E4
SY   MDCK9B9-1E4
DR   ATCC; PTA-7910
DR   Wikidata; Q54904762
RX   Patent=US8846032;
RX   PubMed=20307595;
RX   PubMed=22902973;
CC   Group: Patented cell line.
CC   Group: Vaccine production cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); PTA-7910.
CC   Characteristics: Not tumorigenic. Highly permissive to the live attenuated influenza vaccine (LAIV) components.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: Cocker Spaniel.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_0422 ! MDCK
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 13-07-16; Last updated: 05-10-23; Version: 9
RX   Patent=US8846032;
RA   Liu J., Schwartz R., Thompson M., Maranga L., Ghosh M., Subramanian A.,
RA   Hsu S.S.-T.;
RT   "MDCK cell lines supporting viral growth to high titers and bioreactor
RT   process using the same.";
RL   Patent number US8846032, 30-Sep-2014.
RX   PubMed=20307595; DOI=10.1016/j.vaccine.2010.03.005;
RA   Hussain A.I., Cordeiro M., Sevilla E., Liu J.;
RT   "Comparison of egg and high yielding MDCK cell-derived live attenuated
RT   influenza virus for commercial production of trivalent influenza
RT   vaccine: in vitro cell susceptibility and influenza virus replication
RT   kinetics in permissive and semi-permissive cells.";
RL   Vaccine 28:3848-3855(2010).
RX   PubMed=22902973; DOI=10.1016/j.biologicals.2012.06.005;
RA   Vepachedu R.S., Menon A., Hussain A.I., Liu J.;
RT   "Evaluation of tumorigenic potential of high yielding cloned MDCK
RT   cells for live-attenuated influenza vaccine using in vitro growth
RT   characteristics, metastatic gene expression and in vivo nude mice
RT   model.";
RL   Biologicals 40:482-494(2012).