ID   NGC-0295
AC   CVCL_DF66
SY   NGC0295
DR   Wikidata; Q54930462
RX   PubMed=20664524;
RX   PubMed=22113314;
RX   PubMed=22655593;
CC   Biotechnology: Used in NsG0202, an encapsulated cell biodelivery device capable of local delivery of NGF to the brain so at to treat the cognitive decline in Alzheimer disease patients.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7808; NGF.
CC   Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
CC   Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0145 ! ARPE-19
SX   Male
AG   19Y
CA   Spontaneously immortalized cell line
DT   Created: 13-07-16; Last updated: 19-12-24; Version: 11
//
RX   PubMed=20664524; DOI=10.1038/mt.2010.154; PMCID=PMC2997581;
RA   Fjord-Larsen, Lone
RA   Kusk, Philip
RA   Tornoe, Jens
RA   Juliusson, Bengt
RA   Torp, Malene
RA   Bjarkam, Carsten Reidies
RA   Nielsen, Mette S.
RA   Handberg, Aase
RA   Sorensen, Jens Christian Hedemann
RA   Wahlberg, Lars U.
RT   "Long-term delivery of nerve growth factor by encapsulated cell
RT   biodelivery in the Gottingen minipig basal forebrain.";
RL   Mol. Ther. 18:2164-2172(2010).
//
RX   PubMed=22113314; DOI=10.1038/gt.2011.178;
RA   Fjord-Larsen, Lone
RA   Kusk, Philip
RA   Emerich, Dwaine F.
RA   Thanos, Christopher G.
RA   Torp, Malene
RA   Bintz, Briannan
RA   Tornoe, Jens
RA   Johnsen, Anders H.
RA   Wahlberg, Lars U.
RT   "Increased encapsulated cell biodelivery of nerve growth factor in the
RT   brain by transposon-mediated gene transfer.";
RL   Gene Ther. 19:1010-1017(2012).
//
RX   PubMed=22655593; DOI=10.3171/2012.2.JNS11714;
RA   Wahlberg, Lars U.
RA   Lind, Goran
RA   Almqvist, Per M.
RA   Kusk, Philip
RA   Tornoe, Jens
RA   Juliusson, Bengt
RA   Soderman, Michael
RA   Sellden, Eva
RA   Seiger, Ake
RA   Eriksdotter-Jonhagen, Maria
RA   Linderoth, Bengt
RT   "Targeted delivery of nerve growth factor via encapsulated cell
RT   biodelivery in Alzheimer disease: a technology platform for
RT   restorative neurosurgery.";
RL   J. Neurosurg. 117:340-347(2012).
//