ID   NGC-0295
AC   CVCL_DF66
SY   NGC0295
DR   Wikidata; Q54930462
RX   PubMed=20664524;
RX   PubMed=22113314;
RX   PubMed=22655593;
CC   Biotechnology: Used in NsG0202, an encapsulated cell biodelivery device capable of local delivery of NGF to the brain so at to treat the cognitive decline in Alzheimer disease patients.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7808; NGF.
CC   Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
CC   Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0145 ! ARPE-19
SX   Male
AG   19Y
CA   Spontaneously immortalized cell line
DT   Created: 13-07-16; Last updated: 19-12-24; Version: 11
//
RX   PubMed=20664524; DOI=10.1038/mt.2010.154; PMCID=PMC2997581;
RA   Fjord-Larsen L., Kusk P., Tornoe J., Juliusson B., Torp M.,
RA   Bjarkam C.R., Nielsen M.S., Handberg A., Sorensen J.C.H.,
RA   Wahlberg L.U.;
RT   "Long-term delivery of nerve growth factor by encapsulated cell
RT   biodelivery in the Gottingen minipig basal forebrain.";
RL   Mol. Ther. 18:2164-2172(2010).
//
RX   PubMed=22113314; DOI=10.1038/gt.2011.178;
RA   Fjord-Larsen L., Kusk P., Emerich D.F., Thanos C.G., Torp M., Bintz B.,
RA   Tornoe J., Johnsen A.H., Wahlberg L.U.;
RT   "Increased encapsulated cell biodelivery of nerve growth factor in the
RT   brain by transposon-mediated gene transfer.";
RL   Gene Ther. 19:1010-1017(2012).
//
RX   PubMed=22655593; DOI=10.3171/2012.2.JNS11714;
RA   Wahlberg L.U., Lind G., Almqvist P.M., Kusk P., Tornoe J.,
RA   Juliusson B., Soderman M., Sellden E., Seiger A.,
RA   Eriksdotter-Jonhagen M., Linderoth B.;
RT   "Targeted delivery of nerve growth factor via encapsulated cell
RT   biodelivery in Alzheimer disease: a technology platform for
RT   restorative neurosurgery.";
RL   J. Neurosurg. 117:340-347(2012).
//