ID   HG2L7.5c1
AC   CVCL_DC32
DR   cancercelllines; CVCL_DC32
DR   Wikidata; Q54885927
RX   PubMed=26366531;
CC   Population: Caucasian.
CC   Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
CC   Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 27-11-25; Version: 20
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RX   PubMed=26366531; DOI=10.1021/acs.est.5b02906; PMCID=PMC4772899;
RA   Brennan, Jennifer C.
RA   He, Guo-Chun
RA   Tsutsumi, Tomoaki
RA   Zhao, Jing
RA   Wirth, Edward
RA   Fulton, Michael H.
RA   Denison, Michael S.
RT   "Development of species-specific Ah receptor-responsive third
RT   generation CALUX cell lines with enhanced responsiveness and improved
RT   detection limits.";
RL   Environ. Sci. Technol. 49:11903-11912(2015).
//