ID   H1L6.1c3
AC   CVCL_DC23
DR   Wikidata; Q54871989
RX   PubMed=18969542;
RX   PubMed=21872055;
RX   PubMed=26366531;
WW   https://www.epa.gov/hw-sw846/sw-846-test-method-4435-screening-dioxin-chemical-activity-soils-and-sediments-using-calux
WW   http://www.dioxins.com/calux2.html
CC   Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists.
CC   Biotechnology: Used in US Environmental Protection Agency (EPA) hazardous waste test method 4435 (SW-846).
CC   Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Breed/subspecies: C57L.
DI   NCIt; C38756; Hepatocellular carcinoma of the mouse
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_0328 ! Hepa-1c1c7
SX   Female
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 29-06-23; Version: 9
//
RX   PubMed=18969542; DOI=10.1016/j.talanta.2004.05.032;
RA   Denison M.S., Zhao B., Baston D.S., Clark G.C., Murata H., Han D.;
RT   "Recombinant cell bioassay systems for the detection and relative
RT   quantitation of halogenated dioxins and related chemicals.";
RL   Talanta 63:1123-1133(2004).
//
RX   PubMed=21872055; DOI=10.1016/j.talanta.2011.07.042;
RA   Van Langenhove K., Croes K., Denison M.S., Elskens M., Baeyens W.;
RT   "The CALUX bio-assay: analytical comparison between mouse hepatoma
RT   cell lines with a low (H1L6.1c3) and high (H1L7.5c1) number of dioxin
RT   response elements.";
RL   Talanta 85:2039-2046(2011).
//
RX   PubMed=26366531; DOI=10.1021/acs.est.5b02906;
RA   Brennan J.C., He G.-C., Tsutsumi T., Zhao J., Wirth E., Fulton M.H.,
RA   Denison M.S.;
RT   "Development of species-specific Ah receptor-responsive third
RT   generation CALUX cell lines with enhanced responsiveness and improved
RT   detection limits.";
RL   Environ. Sci. Technol. 49:11903-11912(2015).
//