ID   hmel9
AC   CVCL_D723
DR   cancercelllines; CVCL_D723
DR   Cosmic; 1676367
DR   Cosmic; 2051676
DR   Wikidata; Q54889926
RX   PubMed=21880213;
RX   PubMed=23489693;
RX   PubMed=27540956;
CC   Population: Caucasian; Italian.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Arg (c.1798_1799delGTinsAG); ClinVar=VCV000375940; Zygosity=Homozygous (PubMed=21880213; PubMed=23489693).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   65Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 14
//
RX   PubMed=21880213;
RA   Zanna P., Maida I., Turpin Sevilla M.C., Susca F.C., Filotico R.,
RA   Arciuli M., Cassano N., Vena G.A., Cicero R., Guida G.;
RT   "Molecular characterization of novel melanoma cell lines.";
RL   J. Biol. Regul. Homeost. Agents 25:239-247(2011).
//
RX   PubMed=23489693;
RA   Zanna P., Maida I., Grieco C., Guida S., Turpin Sevilla M.C.,
RA   De Summa S., Tommasi S., Vena G.A., Filotico R., Guida G.;
RT   "Three novel human sporadic melanoma cell lines: signaling pathways
RT   controlled by MC1R, BRAF and beta-catenins.";
RL   J. Biol. Regul. Homeost. Agents 27:131-141(2013).
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RX   PubMed=27540956; DOI=10.1111/pcmr.12516;
RA   Guida M., Strippoli S., Ferretta A., Bartolomeo N., Porcelli L.,
RA   Maida I., Azzariti A., Tommasi S., Grieco C., Guida S., Albano A.,
RA   Lorusso V., Guida G.;
RT   "Detrimental effects of melanocortin-1 receptor (MC1R) variants on the
RT   clinical outcomes of BRAF V600 metastatic melanoma patients treated
RT   with BRAF inhibitors.";
RL   Pigment Cell Melanoma Res. 29:679-687(2016).
//