ID   PK-9 [Human]
AC   CVCL_D721
SY   PK 9; Pk 9; PK9
DR   BTO; BTO:0005486
DR   cancercelllines; CVCL_D721
DR   ChEMBL-Cells; CHEMBL4295487
DR   ChEMBL-Targets; CHEMBL4296486
DR   Cosmic; 707255
DR   Cosmic; 1066178
DR   Cosmic; 1644299
DR   GEO; GSM862568
DR   GEO; GSM862570
DR   GEO; GSM1588618
DR   GEO; GSM1588630
DR   IARC_TP53; 14303
DR   PubChem_Cell_line; CVCL_D721
DR   RCB; RCB2140
DR   TKG; TKG 0240
DR   Wikidata; Q54947461
RX   CelloPub=CLPUB00416;
RX   PubMed=3547771;
RX   PubMed=7622937;
RX   PubMed=8872523;
RX   PubMed=11115575;
RX   PubMed=15770730;
RX   PubMed=16912165;
RX   PubMed=22490663;
CC   Population: Japanese.
CC   Doubling time: 72 hours (PubMed=3547771; PubMed=7622937); 51.4 hours (PubMed=8872523).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=11115575; PubMed=22490663).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (PubMed=11115575; PubMed=22490663).
CC   Omics: Transcriptome analysis by microarray.
CC   Discontinued: RCB; RCB2140; true.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
ST   Source(s): TKG=TKG 0240
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 9,10
ST   D16S539: 12
ST   D5S818: 11,12
ST   D7S820: 11
ST   TH01: 9
ST   TPOX: 9,11
ST   vWA: 15,19
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 02-05-24; Version: 23
//
RX   CelloPub=CLPUB00416;
RA   Oberlin L.;
RT   "Treatment of pancreatic carcinoma cell lines in vitro and vivo with a
RT   monoclonal antibody against the transferrin receptor.";
RL   Thesis VMD (2009), Justus-Liebig-Universitat Giessen, Germany.
//
RX   PubMed=3547771; DOI=10.1620/tjem.150.231;
RA   Kobari M., Hisano H., Matsuno S., Sato T., Kan M., Tachibana T.;
RT   "Establishment of six human pancreatic cancer cell lines and their
RT   sensitivities to anti-tumor drugs.";
RL   Tohoku J. Exp. Med. 150:231-248(1986).
//
RX   PubMed=7622937; DOI=10.1007/BF02788531;
RA   Amikura K., Kobari M., Matsuno S.;
RT   "The time of occurrence of liver metastasis in carcinoma of the
RT   pancreas.";
RL   Int. J. Pancreatol. 17:139-146(1995).
//
RX   PubMed=8872523; DOI=10.1007/BF02787375;
RA   Kimura Y., Kobari M., Yusa T., Sunamura M., Kimura M., Shimamura H.,
RA   Matsuno S.;
RT   "Establishment of an experimental liver metastasis model by
RT   intraportal injection of a newly derived human pancreatic cancer cell
RT   line (KLM-1).";
RL   Int. J. Pancreatol. 20:43-50(1996).
//
RX   PubMed=11115575; DOI=10.3892/or.8.1.89;
RA   Sun C.-L., Yamato T., Furukawa T., Ohnishi Y., Kijima H., Horii A.;
RT   "Characterization of the mutations of the K-ras, p53, p16, and SMAD4
RT   genes in 15 human pancreatic cancer cell lines.";
RL   Oncol. Rep. 8:89-92(2001).
//
RX   PubMed=15770730; DOI=10.3748/wjg.v11.i10.1521;
RA   Ma J.-H., Patrut E., Schmidt J., Knaebel H.-P., Buchler M.W.,
RA   Marten A.;
RT   "Synergistic effects of interferon-alpha in combination with
RT   chemoradiation on human pancreatic adenocarcinoma.";
RL   World J. Gastroenterol. 11:1521-1528(2005).
//
RX   PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721;
RA   Calhoun E.S., Hucl T., Gallmeier E., West K.M., Arking D.E.,
RA   Maitra A., Iacobuzio-Donahue C.A., Chakravarti A., Hruban R.H.,
RA   Kern S.E.;
RT   "Identifying allelic loss and homozygous deletions in pancreatic
RT   cancer without matched normals using high-density single-nucleotide
RT   polymorphism arrays.";
RL   Cancer Res. 66:7920-7928(2006).
//
RX   PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122;
RA   Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M.,
RA   Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S.,
RA   Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M.,
RA   Ishida M., Motoi F., Egawa S., Unno M., Horii A.;
RT   "DCK is frequently inactivated in acquired gemcitabine-resistant human
RT   cancer cells.";
RL   Biochem. Biophys. Res. Commun. 421:98-104(2012).
//