ID   MCF-7:WS8
AC   CVCL_D5YA
DR   Wikidata; Q127382749
RX   PubMed=8600466;
RX   PubMed=15862958;
RX   PubMed=24604139;
CC   Population: Caucasian.
CC   Characteristics: Highly sensitive to estrogen-stimulated growth.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 02-05-24; Last updated: 19-12-24; Version: 3
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RX   PubMed=8600466; DOI=10.1093/nar/24.5.962; PMCID=PMC145723;
RA   Pink J.J., Wu S.-Q., Wolf D.M., Bilimoria M.M., Jordan V.C.;
RT   "A novel 80 kDa human estrogen receptor containing a duplication of
RT   exons 6 and 7.";
RL   Nucleic Acids Res. 24:962-969(1996).
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RX   PubMed=15862958; DOI=10.1016/j.jsbmb.2004.12.032;
RA   Lewis-Wambi J.S., Osipo C., Meeke K., Jordan V.C.;
RT   "Estrogen-induced apoptosis in a breast cancer model resistant to
RT   long-term estrogen withdrawal.";
RL   J. Steroid Biochem. Mol. Biol. 94:131-141(2005).
//
RX   PubMed=24604139; DOI=10.3892/ijo.2014.2329; PMCID=PMC4144033;
RA   Sweeney E.E., Fan P., Jordan V.C.;
RT   "Mechanisms underlying differential response to estrogen-induced
RT   apoptosis in long-term estrogen-deprived breast cancer cells.";
RL   Int. J. Oncol. 44:1529-1538(2014).
//