ID   NPC268
AC   CVCL_D5KT
DR   Cell_Model_Passport; SIDM01990
DR   EGA; EGAS00001007172
DR   GEO; GSE233426
DR   Wikidata; Q127382967
RX   PubMed=38358347;
CC   Population: Chinese; Malaysian.
CC   Doubling time: ~4.5 days (PubMed=38358347).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=38358347).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (PubMed=38358347).
CC   Sequence variation: Gene deletion; HGNC; HGNC:7413; MTAP; Zygosity=Homozygous (PubMed=38358347).
CC   Sequence variation: Mutation; HGNC; HGNC:391; AKT1; Simple; p.Glu17Lys (c.49G>A); ClinVar=VCV000013983; Zygosity=Heterozygous (PubMed=38358347).
CC   Sequence variation: Mutation; HGNC; HGNC:1541; CBL; Simple; p.Asp772Glu (c.2316T>G); ClinVar=VCV000477707; Zygosity=Heterozygous (PubMed=38358347).
CC   Sequence variation: Mutation; HGNC; HGNC:1748; CDH1; Simple; p.Arg124His (c.371G>A); ClinVar=VCV000141538; Zygosity=Heterozygous (PubMed=38358347).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Asp7Gly (c.20A>G); ClinVar=VCV001251597; Zygosity=Homozygous (PubMed=38358347).
CC   Sequence variation: Mutation; HGNC; HGNC:9122; PMS2; Simple; p.Leu47Val (c.139C>G); ClinVar=VCV000219785; Zygosity=Heterozygous (PubMed=38358347).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Pharynx, nasopharynx; UBERON=UBERON_0001728.
CC   Cell type: Epithelial cell; CL=CL_0000066.
ST   Source(s): PubMed=38358347
ST   Amelogenin: X
ST   CSF1PO: 9,13
ST   D10S1248: 13,16
ST   D12S391: 21,24
ST   D13S317: 8,9
ST   D16S539: 11,13
ST   D18S51: 15
ST   D19S433: 14.2,16.2
ST   D1S1656: 14,16
ST   D21S11: 30,32.2
ST   D22S1045: 15,17
ST   D2S1338: 23,24
ST   D2S441: 11,14
ST   D3S1358: 16
ST   D5S818: 12,13
ST   D7S820: 11,12
ST   D8S1179: 15
ST   FGA: 24
ST   Penta D: 8,9
ST   Penta E: 11,13
ST   TH01: 7,8
ST   TPOX: 8
ST   vWA: 14,17
DI   NCIt; C54389; Nasopharyngeal differentiated carcinoma
DI   ORDO; Orphanet_150; Nasopharyngeal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   39Y
CA   Cancer cell line
DT   Created: 02-05-24; Last updated: 10-04-25; Version: 4
//
RX   PubMed=38358347; DOI=10.1158/2767-9764.CRC-23-0341; PMCID=PMC10911800;
RA   Chai A.W.-Y., Yee S.-M., Lee H.-M., Abdul Aziz N., Yee P.-S.,
RA   Marzuki M., Wong K.-W., Chiang A.K.-S., Chow L.K.-Y., Dai W.,
RA   Liu T.-F., Tan L.-P., Khoo A.S.-B., Lo K.-W., Lim P.V.-H.,
RA   Rajadurai P., Lightfoot H., Barthorpe S., Garnett M.J., Cheong S.-C.;
RT   "Establishment and characterization of an Epstein-Barr virus-positive
RT   cell line from a non-keratinizing differentiated primary
RT   nasopharyngeal carcinoma.";
RL   Cancer Res. Commun. 4:645-659(2024).
//