ID   T-REx-293
AC   CVCL_D585
SY   T-REx 293; T-REx293; TRex-293; TREx293; T-REx-HEK293; T-REx HEK 293; HEK293-T-REx; HEK293-Trex
DR   BTO; BTO:0005238
DR   CLO; CLO_0037238
DR   Wikidata; Q54971367
WW   https://www.thermofisher.com/order/catalog/product/R71007
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/t/cell-lines-detail-410.html
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/human/T-REx-HEK293_Farnham_protocol.pdf
WW   https://www.ema.europa.eu/en/documents/assessment-report/vaxzevria-previously-covid-19-vaccine-astrazeneca-epar-public-assessment-report_en.pdf
CC   Group: Vaccine production cell line.
CC   Part of: ENCODE project common cell types; tier 3.
CC   Biotechnology: Used for the production of the AstraZeneca SARS-CoV-2 (COVID-19) vaccine (Trade name: Vaxzevria; also known as ChAdOx1-SARS-COV-2 or AZD1222) (DrugBank; DB15656). In the context of the vaccine production, the tetR repressor blocks the expression of the SARS-CoV-2 spike protein gene during production of the recombinant adenoviral vector, thereby optimising vector production.
CC   Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5.
CC   Derived from sampling site: Fetal kidney.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0045 ! HEK293
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 22-10-12; Last updated: 21-03-23; Version: 20
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