ID   HuT 78/SIV/Mne clone E11S
AC   CVCL_D3XX
RX   PubMed=2231688;
RX   PubMed=7707540;
CC   Population: Caucasian.
CC   Virology: Infected with simian immunodeficiency virus isolate Mne (SIV/Mne). Produces virus with large amounts of envelope glycoprotein gp 120 associated with sucrose gradient purified virus. (PubMed=2231688).
CC   Sequence variation: Gene deletion; HGNC; 7208; MPDZ; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C3366; Sezary syndrome
DI   ORDO; Orphanet_3162; Sezary syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0337 ! HuT 78
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 30-01-24; Last updated: 30-01-24; Version: 1
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RX   PubMed=2231688; DOI=10.1111/j.1600-0684.1990.tb00441.x;
RA   Benveniste R.E., Hill R.W., Eron L.J., Csaikl U.M., Knott W.B.,
RA   Henderson L.E., Sowder R.C., Nagashima K., Gonda M.A.;
RT   "Characterization of clones of HIV-1 infected HuT 78 cells defective
RT   in gag gene processing and of SIV clones producing large amounts of
RT   envelope glycoprotein.";
RL   J. Med. Primatol. 19:351-366(1990).
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RX   PubMed=7707540; DOI=10.1128/JVI.69.5.3117-3124.1995;
RA   Arthur L.O., Bess J.W. Jr., Urban R.G., Strominger J.L., Morton W.R.,
RA   Mann D.L., Henderson L.E., Benveniste R.E.;
RT   "Macaques immunized with HLA-DR are protected from challenge with
RT   simian immunodeficiency virus.";
RL   J. Virol. 69:3117-3124(1995).
//