ID   iBMK Atg5-/- 7.1B2
AC   CVCL_D3IV
SY   7.1B2
DR   Wikidata; Q127382112
RX   PubMed=17510285;
RX   PubMed=18603117;
CC   Knockout cell: Method=KO mouse; MGI; MGI:1277186; Atg5.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:990; BCL2.
CC   Genetic integration: Method=Transfection; Gene=MGI; MGI:98834; Trp53 (Note=With p.Leu14_Lys302del = p53DD).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P03255; Adenovirus 5 E1A protein.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5 (Note=E1A).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: C57BL/6.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_D3ID ! iBMK Atg5-/- 7.1
SX   Sex unspecified
AG   <2D
CA   Transformed cell line
DT   Created: 30-01-24; Last updated: 10-04-25; Version: 4
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RX   PubMed=17510285; DOI=10.1101/gad.1545107; PMCID=PMC1877749;
RA   Mathew R., Kongara S., Beaudoin B., Karp C.M., Bray K., Degenhardt K.,
RA   Chen G.-H., Jin S.-K., White E.;
RT   "Autophagy suppresses tumor progression by limiting chromosomal
RT   instability.";
RL   Genes Dev. 21:1367-1381(2007).
//
RX   PubMed=18603117; DOI=10.1016/S0076-6879(08)01605-4;
RA   Mathew R., Degenhardt K., Haramaty L., Karp C.M., White E.;
RT   "Immortalized mouse epithelial cell models to study the role of
RT   apoptosis in cancer.";
RL   Methods Enzymol. 446:77-106(2008).
//