ID   RCC-1
AC   CVCL_D2QP
SY   Raji Co-Culture No.1
RX   Patent=US5849564;
RX   Patent=US5861500;
RX   PubMed=8523568;
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11734.
CC   Population: African; Nigerian.
CC   Virology: Infected with human herpesvirus 8 (HHV-8/KSHV). Produced by the co-cultivation of Raji cells with BC-1 cells (Cellosaurus=CVCL_1079) separated by filter tissue culture inserts to prevent cross-contamination (PubMed=8523568).
CC   Sequence variation: Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0511 ! Raji
SX   Male
AG   11Y
CA   Cancer cell line
DT   Created: 30-01-24; Last updated: 02-05-24; Version: 2
//
RX   Patent=US5849564;
RA   Chang Y., Bohenzky R.A., Russo J.J., Edelman I.S., Moore P.S.;
RT   "Polypeptides from Kaposi's sarcoma-associated herpesvirus, DNA
RT   encoding same and uses thereof.";
RL   Patent number US5849564, 15-Dec-1998.
//
RX   Patent=US5861500;
RA   Chang Y., Bohenzky R.A., Russo J.J., Edelman I.S., Moore P.S.;
RT   "Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin 6 (IL-6)
RT   and uses thereof.";
RL   Patent number US5861500, 19-Jan-1999.
//
RX   PubMed=8523568; DOI=10.1128/JVI.70.1.549-558.1996;
RA   Moore P.S., Gao S.-J., Dominguez G., Cesarman E., Lungu O.,
RA   Knowles D.M., Garber R., Pellett P.E., McGeoch D.J., Chang Y.;
RT   "Primary characterization of a herpesvirus agent associated with
RT   Kaposi's sarcomae.";
RL   J. Virol. 70:549-558(1996).
//