ID   KU-2
AC   CVCL_D267
SY   Ku-2; KU2; Keio University-2
DR   ChEMBL-Cells; CHEMBL3307795
DR   ChEMBL-Targets; CHEMBL612265
DR   PubChem_Cell_line; CVCL_D267
DR   Wikidata; Q54900673
RX   PubMed=311392;
RX   PubMed=661038;
RX   PubMed=1263309;
RX   PubMed=3012186;
RX   PubMed=3022569;
RX   PubMed=7185005;
RX   PubMed=10496353;
CC   Population: Japanese.
CC   Characteristics: Established from a xenograft maintained in nude mice.
CC   Doubling time: 26 hours (PubMed=661038).
CC   Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
DI   NCIt; C9385; Renal cell carcinoma
DI   ORDO; Orphanet_217071; Renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 05-10-23; Version: 15
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RX   PubMed=311392; DOI=10.5980/jpnjurol1928.69.12_1623;
RA   Jistukawa S.;
RT   "Normal human lymphocyte mediated cytotoxicity against an established
RT   cell line (KU-2) derived from human renal cell carcinoma: role to T &
RT   B cells as effector.";
RL   Nihon Hinyokika Gakkai Zasshi 69:1623-1638(1978).
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RX   PubMed=661038; DOI=10.5980/jpnjurol1928.69.3_285;
RA   Katsuoka Y.;
RT   "Functional and morphological observation of human renal cell
RT   carcinoma utilizing nude mouse and cell culture system.";
RL   Nihon Hinyokika Gakkai Zasshi 69:285-303(1978).
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RX   PubMed=1263309; DOI=10.1016/S0022-5347(17)59208-3;
RA   Katsuoka Y., Baba S., Hata M., Tazaki H.;
RT   "Transplantation of human renal cell carcinoma to the nude mice: as an
RT   intermediate of in vivo and in vitro studies.";
RL   J. Urol. 115:373-376(1976).
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RX   PubMed=3012186; DOI=10.1038/ki.1986.74;
RA   Nagakura K., Abe E., Suda T., Hayakawa M., Nakamura H., Tazaki H.;
RT   "Inhibitory effect of 1 alpha,25-dihydroxyvitamin D3 on the growth of
RT   the renal carcinoma cell line.";
RL   Kidney Int. 29:834-840(1986).
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RX   PubMed=3022569;
RA   Katsuoka Y.;
RT   "Characteristics of an established cell line (KU-2) derived from human
RT   renal cell carcinoma: I. Cloning of cells and morphological study of
RT   clones; II. Cell kinetics of KU-2 cells; III. Detection of type C
RT   virus in the culture.";
RL   Hinyokika Kiyo 32:941-948(1986).
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RX   PubMed=7185005; DOI=10.2302/kjm.31.55;
RA   Nagakura K.;
RT   "Studies on heterogeneity of cultured cell line (KU-2) derived from
RT   human renal cell carcinoma: morphology, karyotypes and growth kinetics
RT   based on analysis of 13 clones.";
RL   Keio J. Med. 31:55-69(1982).
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RX   PubMed=10496353; DOI=10.1038/sj.bjc.6690688; PMCID=PMC2362876;
RA   Sumitomo M., Tachibana M., Murai M., Hayakawa M., Nakamura H.,
RA   Takayanagi A., Shimizu N.;
RT   "Overexpression of IL-1ra gene up-regulates interleukin-1beta
RT   converting enzyme (ICE) gene expression: possible mechanism underlying
RT   IL-1beta-resistance of cancer cells.";
RL   Br. J. Cancer 81:277-286(1999).
//