ID   HeLa-MAGI-CCR5
AC   CVCL_D260
SY   HeLa-CD4-CCR5; MAGI-CCR5; MAGI-CCR-5
DR   BTO; BTO_0003587
DR   CLO; CLO_0037219
DR   BEI_Resources; ARP-3522
DR   Wikidata; Q54882720
RX   PubMed=9094670;
RX   PubMed=9201229;
RX   PubMed=11158746;
WW   Info; IdeaConnection; -; https://www.ideaconnection.com/patents/3382-MAGI-CCR5-Cells.html
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-559.html
CC   Population: African American.
CC   Characteristics: Can be used to can be used to screen for anti-HIV-1 drugs (PubMed=9094670).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1606; CCR5.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1678; CD4.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_D259 ! HeLa-MAGI
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 25
//
RX   PubMed=9094670; DOI=10.1128/JVI.71.5.3932-3939.1997; PMCID=PMC191545;
RA   Chackerian B., Long E.M., Luciw P.A., Overbaugh J.;
RT   "Human immunodeficiency virus type 1 coreceptors participate in
RT   postentry stages in the virus replication cycle and function in simian
RT   immunodeficiency virus infection.";
RL   J. Virol. 71:3932-3939(1997).
//
RX   PubMed=9201229; DOI=10.1006/viro.1997.8606;
RA   Vodicka M.A., Goh W.C., Wu L.I., Rogel M.E., Bartz S.R.,
RA   Schweickart V.L., Raport C.J., Emerman M.;
RT   "Indicator cell lines for detection of primary strains of human and
RT   simian immunodeficiency viruses.";
RL   Virology 233:193-198(1997).
//
RX   PubMed=11158746; DOI=10.1128/AAC.45.2.495-501.2001; PMCID=PMC90318;
RA   Hachiya A., Aizawa-Matsuoka S., Tanaka M., Takahashi Y., Ida S.,
RA   Gatanaga H., Hirabayashi Y., Kojima A., Tatsumi M., Oka S.;
RT   "Rapid and simple phenotypic assay for drug susceptibility of human
RT   immunodeficiency virus type 1 using CCR5-expressing HeLa/CD4(+) cell
RT   clone 1-10 (MAGIC-5).";
RL   Antimicrob. Agents Chemother. 45:495-501(2001).
//