ID   SCN2.2
AC   CVCL_D050
SY   SCN 2.2
DR   EFO; EFO_0002708
DR   ABM; T0296
DR   CancerTools; 160400
DR   GEO; GSM28447
DR   GEO; GSM28448
DR   GEO; GSM28449
DR   GEO; GSM28450
DR   GEO; GSM28451
DR   GEO; GSM28452
DR   GEO; GSM28453
DR   GEO; GSM28454
DR   GEO; GSM28455
DR   GEO; GSM28456
DR   GEO; GSM28458
DR   GEO; GSM28459
DR   GEO; GSM28460
DR   GEO; GSM28461
DR   GEO; GSM28462
DR   GEO; GSM28463
DR   GEO; GSM28464
DR   GEO; GSM28465
DR   GEO; GSM28466
DR   GEO; GSM28467
DR   GEO; GSM28468
DR   GEO; GSM28469
DR   GEO; GSM28470
DR   GEO; GSM28471
DR   GEO; GSM28472
DR   GEO; GSM28473
DR   GEO; GSM28474
DR   Kerafast; EUT500
DR   Wikidata; Q54952478
RX   PubMed=10213449;
RX   PubMed=15769907;
RX   PubMed=17284666;
CC   Characteristics: Capable to differentiate into different phenotypes. Expresses the neuronal markers (NSE, PGP and MAP2), but absent of glial markers. Valuable tool for studies relating to the regulation of the central mammalian pacemaker function and the development of the suprachiasmatic nucleus (SCN) cell types (Kerafast=EUT500).
CC   Doubling time: 28 hours (PubMed=10213449).
CC   Transformant: Psi2 defective retrovirus adenovirus E1A.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Embryonic brain, hypothalamus, suprachiasmatic nucleus; UBERON=UBERON_0006238+UBERON_0002034.
CC   Breed/subspecies: Long-Evans; RS=RS_0000347.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Sex unspecified
AG   15-16FD
CA   Transformed cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 14
//
RX   PubMed=10213449; DOI=10.1002/(SICI)1097-4695(199904)39:1<1::AID-NEU1>3.0.CO;2-F;
RA   Earnest D.J., Liang F.-Q., DiGiorgio S., Gallagher M., Harvey B.K.,
RA   Earnest B., Seigel G.M.;
RT   "Establishment and characterization of adenoviral E1A immortalized
RT   cell lines derived from the rat suprachiasmatic nucleus.";
RL   J. Neurobiol. 39:1-13(1999).
//
RX   PubMed=15769907; DOI=10.1152/physiolgenomics.00224.2004;
RA   Menger G.J., Lu K., Thomas T.L., Cassone V.M., Earnest D.J.;
RT   "Circadian profiling of the transcriptome in immortalized rat SCN
RT   cells.";
RL   Physiol. Genomics 21:370-381(2005).
//
RX   PubMed=17284666; DOI=10.1152/physiolgenomics.00199.2006;
RA   Menger G.J., Allen G.C., Neuendorff N., Nahm S.-S., Thomas T.L.,
RA   Cassone V.M., Earnest D.J.;
RT   "Circadian profiling of the transcriptome in NIH/3T3 fibroblasts:
RT   comparison with rhythmic gene expression in SCN2.2 cells and the rat
RT   SCN.";
RL   Physiol. Genomics 29:280-289(2007).
//