ID   G1E
AC   CVCL_D046
SY   GATA-1(-) Erythroid
DR   EFO; EFO_0002034
DR   ENCODE; ENCBS159ZTO
DR   ENCODE; ENCBS324ENC
DR   ENCODE; ENCBS431QXW
DR   ENCODE; ENCBS503ARZ
DR   ENCODE; ENCBS566SQH
DR   ENCODE; ENCBS602TAQ
DR   ENCODE; ENCBS807UWB
DR   Wikidata; Q54835375
RX   PubMed=9032291;
RX   PubMed=10381501;
RX   PubMed=12832487;
RX   PubMed=25729644;
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/mouse/G1E_Hardison_protocol.pdf
CC   Part of: ENCODE project mouse cell lines.
CC   Characteristics: Proliferates continuously in culture as immature erythroblasts and undergo terminal maturation when Gata1 function is restored.
CC   Characteristics: EPO and KITLG dependent.
CC   Doubling time: ~12 hours (ENCODE=ENCBS159ZTO).
CC   Transfected with: HGNC; 990; BCL2.
CC   Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
CC   Cell type: Embryonic stem cell; CL=CL_0002322.
CC   Breed/subspecies: 129S/SvEv-Gpi1.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_WI94 ! GATA-1- ES cell clone 74
SX   Male
AG   Blastocyst stage
CA   Embryonic stem cell
DT   Created: 22-10-12; Last updated: 02-05-24; Version: 15
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RX   PubMed=9032291; DOI=10.1128/mcb.17.3.1642;
RA   Weiss M.J., Yu C., Orkin S.H.;
RT   "Erythroid-cell-specific properties of transcription factor GATA-1
RT   revealed by phenotypic rescue of a gene-targeted cell line.";
RL   Mol. Cell. Biol. 17:1642-1651(1997).
//
RX   PubMed=10381501; DOI=10.1182/blood.V94.1.87.413k41_87_96;
RA   Gregory T., Yu C., Ma A., Orkin S.H., Blobel G.A., Weiss M.J.;
RT   "GATA-1 and erythropoietin cooperate to promote erythroid cell
RT   survival by regulating bcl-xL expression.";
RL   Blood 94:87-96(1999).
//
RX   PubMed=12832487; DOI=10.1128/mcb.23.14.5031-5042.2003;
RA   Rylski M., Welch J.J., Chen Y.-Y., Letting D.L., Diehl J.A.,
RA   Chodosh L.A., Blobel G.A., Weiss M.J.;
RT   "GATA-1-mediated proliferation arrest during erythroid maturation.";
RL   Mol. Cell. Biol. 23:5031-5042(2003).
//
RX   PubMed=25729644; DOI=10.1016/j.gdata.2015.01.008;
RA   Jain D., Mishra T., Giardine B.M., Keller C.A., Morrissey C.S.,
RA   Magargee S.P., Dorman C.M., Long M., Weiss M.J., Hardison R.C.;
RT   "Dynamics of GATA1 binding and expression response in a GATA1-induced
RT   erythroid differentiation system.";
RL   Genom. Data 4:1-7(2015).
//