ID   M21
AC   CVCL_D031
SY   UCLA-SO-M21; UCLA SO M21
DR   cancercelllines; CVCL_D031
DR   ChEMBL-Cells; CHEMBL3307769
DR   ChEMBL-Targets; CHEMBL614117
DR   Cosmic; 928695
DR   Cosmic; 2757120
DR   ESTDAB; ESTDAB-042
DR   PubChem_Cell_line; CVCL_D031
DR   Wikidata; Q54903519
RX   PubMed=1376331;
RX   PubMed=2447074;
RX   PubMed=6386801;
RX   PubMed=15592718;
RX   PubMed=24732172;
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-388.html
CC   HLA typing: A*03:01,02:01; B*07:02; C*07:02; DPB1*04:01; DQB1*06:02,03:01:01; DRB1*11:01,15:01 (PubMed=15592718).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=24732172).
CC   Derived from site: Metastatic; Not specified.
ST   Source(s): ESTDAB=ESTDAB-042
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 8,9
ST   D3S1358: 14,18
ST   D5S818: 10,13
ST   D7S820: 10,12
ST   FGA: 20
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 14
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 22
//
RX   PubMed=1376331; DOI=10.1172/JCI115811; PMCID=PMC295910;
RA   Felding-Habermann B., Mueller B.M., Romerdahl C.A., Cheresh D.A.;
RT   "Involvement of integrin alpha V gene expression in human melanoma
RT   tumorigenicity.";
RL   J. Clin. Invest. 89:2018-2022(1992).
//
RX   PubMed=2447074; DOI=10.1016/S0021-9258(18)45436-1;
RA   Cheresh D.A., Spiro R.C.;
RT   "Biosynthetic and functional properties of an Arg-Gly-Asp-directed
RT   receptor involved in human melanoma cell attachment to vitronectin,
RT   fibrinogen, and von Willebrand factor.";
RL   J. Biol. Chem. 262:17703-17711(1987).
//
RX   PubMed=6386801; DOI=10.1016/S0021-9258(18)90807-0;
RA   Bumol T.F., Walker L.E., Reisfeld R.A.;
RT   "Biosynthetic studies of proteoglycans in human melanoma cells with a
RT   monoclonal antibody to a core glycoprotein of chondroitin sulfate
RT   proteoglycans.";
RL   J. Biol. Chem. 259:12733-12741(1984).
//
RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A.,
RA   Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G.,
RA   Garrido F.;
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//
RX   PubMed=24732172; DOI=10.18632/oncotarget.1878; PMCID=PMC4039118;
RA   Sabbatino F., Wang Y.-Y., Wang X.-H., Flaherty K.T., Yu L., Pepin D.,
RA   Scognamiglio G., Pepe S., Kirkwood J.M., Cooper Z.A., Frederick D.T.,
RA   Wargo J.A., Ferrone S., Ferrone C.R.;
RT   "PDGFRalpha up-regulation mediated by sonic hedgehog pathway
RT   activation leads to BRAF inhibitor resistance in melanoma cells with
RT   BRAF mutation.";
RL   Oncotarget 5:1926-1941(2014).
//