ID   ES-2/TxT50
AC   CVCL_CZ95
SY   ES-2 TxT50; ES-2TxT50
DR   cancercelllines; CVCL_CZ95
DR   GEO; GSM95429
DR   Progenetix; CVCL_CZ95
DR   Wikidata; Q54832438
RX   PubMed=16382445;
CC   Problematic cell line: Probably misclassified. Parent cell line seems to originate from a Caucasian patient with an ovarian serous adenocarcinoma origin.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_4672; Docetaxel anhydrous (Taxotere).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:26144; PALB2; Simple; p.Lys295_Met296insTer (c.886delA) (p.Met296Terfs); ClinVar=VCV000143979; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.242_243CC>TT (-138/-139CC>TT); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
DI   NCIt; C40078; Ovarian clear cell adenocarcinoma
DI   ORDO; Orphanet_398971; Clear cell adenocarcinoma of the ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3509 ! ES-2
SX   Female
AG   47Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 19-12-24; Version: 14
//
RX   PubMed=16382445; DOI=10.1002/gcc.20300;
RA   Wang, Yan C.
RA   Juric, Dejan
RA   Francisco, Brian
RA   Yu, Ron X.
RA   Duran, George E.
RA   Chen, G. Kevin
RA   Chen, Xin
RA   Sikic, Branimir Ivan
RT   "Regional activation of chromosomal arm 7q with and without gene
RT   amplification in taxane-selected human ovarian cancer cell lines.";
RL   Genes Chromosomes Cancer 45:365-374(2006).
//