ID   A549-SunTag
AC   CVCL_C9AW
DR   BioGRID_ORCS_Cell_line; 1594
DR   Wikidata; Q123030366
RX   PubMed=35421191;
CC   Population: Caucasian.
CC   Characteristics: Doxycycline induces the expression of pCW-TRE-scFv-SunTag. SunTag consists of 24 copies of a short peptide epitope from yeast GCN4 and is used to recruite multiple protein copies to a polypeptide scaffold.
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Omics: Phenotyping; CRISPR screening.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0023 ! A-549
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 10-04-25; Version: 5
//
RX   PubMed=35421191; DOI=10.1371/journal.ppat.1010464; PMCID=PMC9041830;
RA   Danziger O., Patel R.S., DeGrace E.J., Rosen M.R., Rosenberg B.R.;
RT   "Inducible CRISPR activation screen for interferon-stimulated genes
RT   identifies OAS1 as a SARS-CoV-2 restriction factor.";
RL   PLoS Pathog. 18:e1010464.1-e1010464.31(2022).
//