ID   10326
AC   CVCL_C8Z0
DR   Wikidata; Q123030198
RX   PubMed=17934517;
RX   PubMed=21447744;
RX   PubMed=29348827;
CC   Sequence variation: Gene fusion; HGNC; HGNC:1104; BRD3 + HGNC; HGNC:29919; NUTM1; Name(s)=BRD3-NUTM1, BRD3-NUT; Note=BRD3 exon 15 fused to NUTM1 exon 2 (PubMed=17934517; PubMed=29348827).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
DI   NCIt; C45716; NUT carcinoma
DI   ORDO; Orphanet_443167; NUT midline carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 10-04-25; Version: 4
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RX   PubMed=17934517; DOI=10.1038/sj.onc.1210852;
RA   French C.A., Ramirez C.L., Kolmakova J., Hickman T.T., Cameron M.J.,
RA   Thyne M.E., Kutok J.L., Toretsky J.A., Tadavarthy A.K., Kees U.R.,
RA   Fletcher J.A., Aster J.C.;
RT   "BRD-NUT oncoproteins: a family of closely related nuclear proteins
RT   that block epithelial differentiation and maintain the growth of
RT   carcinoma cells.";
RL   Oncogene 27:2237-2242(2008).
//
RX   PubMed=21447744; DOI=10.1158/0008-5472.CAN-10-3513; PMCID=PMC3070805;
RA   Schwartz B.E., Hofer M.D., Lemieux M.E., Bauer D.E., Cameron M.J.,
RA   West N.H., Agoston E.S., Reynoird N., Khochbin S., Ince T.A.,
RA   Christie A.L., Janeway K.A., Vargas S.O., Perez-Atayde A.R., Aster J.C.,
RA   Sallan S.E., Kung A.L., Bradner J.E., French C.A.;
RT   "Differentiation of NUT midline carcinoma by epigenomic
RT   reprogramming.";
RL   Cancer Res. 71:2686-2696(2011).
//
RX   PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512;
RA   Stirnweiss A., Oommen J., Kotecha R.S., Kees U.R., Beesley A.H.;
RT   "Molecular-genetic profiling and high-throughput in vitro drug
RT   screening in NUT midline carcinoma-an aggressive and fatal disease.";
RL   Oncotarget 8:112313-112329(2017).
//