ID   CUTO-14
AC   CVCL_C8TF
SY   CUTO14; Colorado University Thoracic Oncology 14
DR   Wikidata; Q123030986
RX   PubMed=29686424;
RX   PubMed=33355298;
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Val769_Asp770insAlaSerVal (c.2308_2309insCCAGCGTGG) (c.2300_2308dup) (M766_A767insASV) (p.Ala767_Val769dupAlaSerVal) (A767_V769dupASV); ClinVar=VCV000177678; Zygosity=Heterozygous (PubMed=33355298).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 10-04-25; Version: 4
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RX   PubMed=29686424; DOI=10.1038/s41591-018-0007-9; PMCID=PMC5964608;
RA   Robichaux J.P., Elamin Y.Y., Tan Z., Carter B.W., Zhang S.-X.,
RA   Liu S.-W., Li S., Chen T., Poteete A., Estrada-Bernal A., Le A.T.,
RA   Truini A., Nilsson M.B., Sun H.-Y., Roarty E., Goldberg S.B.,
RA   Brahmer J.R., Altan M., Lu C., Papadimitrakopoulou V., Politi K.,
RA   Doebele R.C., Wong K.-K., Heymach J.V.;
RT   "Mechanisms and clinical activity of an EGFR and HER2 exon
RT   20-selective kinase inhibitor in non-small cell lung cancer.";
RL   Nat. Med. 24:638-646(2018).
//
RX   PubMed=33355298; DOI=10.1158/1078-0432.CCR-20-3555; PMCID=PMC7926264;
RA   Estrada-Bernal A., Le A.T., Doak A.E., Tirunagaru V.G., Silva S.,
RA   Bull M.R., Smaill J.B., Patterson A.V., Kim C., Liu S.V.,
RA   Doebele R.C.;
RT   "Tarloxotinib is a hypoxia-activated pan-HER kinase inhibitor active
RT   against a broad range of HER-family oncogenes.";
RL   Clin. Cancer Res. 27:1463-1475(2021).
//