ID   Huh-7 clone 5-15
AC   CVCL_C8QS
DR   Wikidata; Q123032640
RX   PubMed=10390360;
RX   PubMed=11152498;
CC   Population: Japanese.
CC   Virology: Harbors a self-replicating bicistronic hepatitis C virus (HCV) genotype 1b subgenomic replicon (PubMed=10390360; PubMed=11152498).
CC   Doubling time: 25.5 +- 2.5 hours (PubMed=11152498).
CC   Sequence variation: Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0336 ! Huh-7
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 14-08-25; Version: 5
//
RX   PubMed=10390360; DOI=10.1126/science.285.5424.110;
RA   Lohmann, Volker
RA   Korner, Frank
RA   Koch, Jan Oliver
RA   Herian, Ulrike
RA   Theilmann, Lorenz
RA   Bartenschlager, Ralf Friedrich Wilhelm
RT   "Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell
RT   line.";
RL   Science 285:110-113(1999).
//
RX   PubMed=11152498; DOI=10.1128/JVI.75.3.1252-1264.2001; PMCID=PMC114031;
RA   Pietschmann, Thomas
RA   Lohmann, Volker
RA   Rutter, Gabriel
RA   Kurpanek, Katharina
RA   Bartenschlager, Ralf Friedrich Wilhelm
RT   "Characterization of cell lines carrying self-replicating hepatitis C
RT   virus RNAs.";
RL   J. Virol. 75:1252-1264(2001).
//