ID   HF2303
AC   CVCL_C8P8
SY   HF-2303
DR   BTO; BTO_0006543
DR   Wikidata; Q123031641
RX   PubMed=27564115;
RX   PubMed=32064048;
CC   Group: Cancer stem cell line.
CC   Doubling time: 179 hours (PubMed=32064048).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Unspecified (PubMed=32064048).
CC   Miscellaneous: Established both as a cell culture and a neurosphere.
CC   Derived from site: In situ; Brain, left parietal lobe; UBERON=UBERON_0002802.
DI   NCIt; C3796; Gliosarcoma
DI   ORDO; Orphanet_251576; Gliosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 19-12-24; Version: 3
//
RX   PubMed=27564115; DOI=10.18632/oncotarget.11589; PMCID=PMC5325344;
RA   Wilson T.J., Zamler D.B., Doherty R., Castro M.G., Lowenstein P.R.;
RT   "Reversibility of glioma stem cells' phenotypes explains their complex
RT   in vitro and in vivo behavior: Discovery of a novel
RT   neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using
RT   the genomic landscape of human glioma stem cells as a discovery
RT   tool.";
RL   Oncotarget 7:63020-63041(2016).
//
RX   PubMed=32064048; DOI=10.18632/oncotarget.27457; PMCID=PMC6996910;
RA   Ye L.F., Reznik E., Korn J.M., Lin F., Yang G.-Z., Malesky K., Gao H.,
RA   Loo A., Pagliarini R., Mikkelsen T., Lo D.C., deCarvalho A.C.,
RA   Stockwell B.R.;
RT   "Patient-derived glioblastoma cultures as a tool for small-molecule
RT   drug discovery.";
RL   Oncotarget 11:443-451(2020).
//